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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Pamidronate

Pamidronate Disodium 30 mg/vial

$86.09

vial

* price without discount in nearest pharmacy. Price may vary.

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Pamidronate volume of distribution

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What is Pamidronate

Pamidronic acid (INN) or pamidronate disodium (USAN), marketed as pamidronate disodium pentahydrate under the brand name Aredia, is a bisphosphonate. (Wikipedia)

Pamidronate mechanism of action

The mechanism of action of pamidronate is inhibition of bone resorption. Pamidronate adsorbs to calcium phosphate (hydroxyapatite) crystals in bone and may directly block dissolution of this mineral component of bone. In vitro studies also suggest that inhibition of osteoclast activity contributes to inhibition of bone resorption. Pamidronate also targets farnesyl pyrophosphate (FPP) synthase. Nitrogen-containing bisphosphonates (such as pamidronate, alendronate, risedronate, ibandronate and zoledronate) appear to act as analogues of isoprenoid diphosphate lipids, thereby inhibiting FPP synthase, an enzyme in the mevalonate pathway. Inhibition of this enzyme in osteoclasts prevents the biosynthesis of isoprenoid lipids (FPP and GGPP) that are essential for the post-translational farnesylation and geranylgeranylation of small GTPase signalling proteins. This activity inhibits osteoclast activity and reduces bone resorption and turnover. In postmenopausal women, it reduces the elevated rate of bone turnover, leading to, on average, a net gain in bone mass.

Dosage forms of Pamidronate

FormRouteStrength
Powder for solutionintravenous60 mg
Liquidintravenous3 mg
Injectionintravenous3 mg/mL
Prescription Generics

false

International Brands

Aredia

Synonyms

Acide pamidronique Acido pamidronico

Manufacturers

Novartis Pharmaceuticals Canada Inc

CAS number

40391-99-9

UNII

OYY3447OMC

State

solid

Affected organisms

Humans and other mammals

Indication of Pamidronate

For the treatment of moderate or severe hypercalcemia associated with malignancy

Toxicity of Pamidronate

Side effects include an allergic reaction, kidney problems, seizures, low levels of calcium, magnesium, or phosphorus in the blood

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