Save up -80% on Parathyroid hormone

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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Natpara

$9,5691 carton (2 cartridges) 50mcg/dose
Price with discount in nearest pharmacy. Price may vary.

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Parathyroid hormone volume of distribution

The volume of distribution at steady-state following intravenous administration is approximately 5.4 liters. Intersubject variability is about 40%.

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2018 Statistics

discount card

Discount Cards 16,000+

benefit

Clients Benefit 29%

savings

Total savings $4,735,080

What is Parathyroid hormone

Parathyroid hormone (PTH) is a single-chain polypeptide composed of 84 amino acids. As Preotact, it contains recombinant human parathyroid hormone which is identical to the full-length native 84-amino acid polypeptide. It is produced as a fusion protein. Post-translational processing involves the cleavage of the OmpA leader sequence, leaving the mature protein as a single-chain 84 amino-acids polypeptide (9.4 kDa) whose sequence is identical to that of the full-length native endogenous human PTH. It has no disulfide bonds and no glycosylation sites. Preotact is used in the treatment of osteoporosis in postmenopausal women at high risk of osteoporotic fractures. Preotact is marketed in Europe by Nycomed. Preos is a registered trade mark owned by NPS Pharmaceuticals, Inc. The name Preos and the New Drug Application is pending approval by the U.S. Food and Drug Administration (FDA).

Parathyroid hormone mechanism of action

The biological actions of rhPTH are mediated through binding to at least two distinct high- affinity cell-surface receptors specific for the N-terminal and C-terminal regions of the molecule, both of which are required for normal bone metabolism. The N-terminal portion of the molecule is primarily responsible for the bone building effects of parathyroid hormone. The C-terminal portion of the molecule has antiresorptive activity and is necessary for normal regulation of N-terminal fragment activity.

Dosage forms of Parathyroid hormone

FormRouteStrength
Injection, powder, lyophilized, for solutionsubcutaneous100 ug/.08mL
Injection, powder, lyophilized, for solutionsubcutaneous25 ug/.08mL
Injection, powder, lyophilized, for solutionsubcutaneous50 ug/.08mL

Prescription Generics

false

International Brands

Natpara (parathyroid Hormone)

Synonyms

hPTH hPTH(1-84)

Manufacturers

Shire Nps Pharmaceuticals, Inc.

CAS number

9002-64-6

UNII

N19A0T0E5J

State

solid

Affected organisms

Humans and other mammals

Indication of Parathyroid hormone

For use/treatment in osteoporosis.

Toxicity of Parathyroid hormone

Toxicity of parathyroid hormone in uremia. The most significant complication of elevated parathyroid hormone (PTH) levels in uremia is the development of osteitis fibrosa cystica. A role for PTH in heart and skeletal muscle dysfunction in uremia has not been clearly established.

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