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2018 Price of Parathyroid hormone
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Parathyroid hormone volume of distribution
The volume of distribution at steady-state following intravenous administration is approximately 5.4 liters. Intersubject variability is about 40%.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Parathyroid hormone
Parathyroid hormone (PTH) is a single-chain polypeptide composed of 84 amino acids. As Preotact, it contains recombinant human parathyroid hormone which is identical to the full-length native 84-amino acid polypeptide. It is produced as a fusion protein. Post-translational processing involves the cleavage of the OmpA leader sequence, leaving the mature protein as a single-chain 84 amino-acids polypeptide (9.4 kDa) whose sequence is identical to that of the full-length native endogenous human PTH. It has no disulfide bonds and no glycosylation sites. Preotact is used in the treatment of osteoporosis in postmenopausal women at high risk of osteoporotic fractures. Preotact is marketed in Europe by Nycomed. Preos is a registered trade mark owned by NPS Pharmaceuticals, Inc. The name Preos and the New Drug Application is pending approval by the U.S. Food and Drug Administration (FDA).
Parathyroid hormone mechanism of action
The biological actions of rhPTH are mediated through binding to at least two distinct high- affinity cell-surface receptors specific for the N-terminal and C-terminal regions of the molecule, both of which are required for normal bone metabolism. The N-terminal portion of the molecule is primarily responsible for the bone building effects of parathyroid hormone. The C-terminal portion of the molecule has antiresorptive activity and is necessary for normal regulation of N-terminal fragment activity.
Dosage forms of Parathyroid hormone
|Injection, powder, lyophilized, for solution||subcutaneous||100 ug/.08mL|
|Injection, powder, lyophilized, for solution||subcutaneous||25 ug/.08mL|
|Injection, powder, lyophilized, for solution||subcutaneous||50 ug/.08mL|
Natpara (parathyroid Hormone)
Shire Nps Pharmaceuticals, Inc.
Humans and other mammals
Indication of Parathyroid hormone
For use/treatment in osteoporosis.
Toxicity of Parathyroid hormone
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