Save up -80% on Pegaspargase

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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Pegaspargase

Oncaspar 750 unit/ml vial

$656.0

ml

* price without discount in nearest pharmacy. Price may vary.

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Pegaspargase volume of distribution

IV: Adults (asparaginase naive): 2.4 L/m2 ; Distributes into CSF (reportedly reducing CSF asparagine concentrations to a similar extent as asparaginase

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What is Pegaspargase

Pegylated L-asparagine amidohydrolase from E. coli. Pegylation substantially (by a factor of 4) extends the protein half life.

Pegaspargase mechanism of action

Pegaspargase, more effective than asparaginase, converts asparagine to aspartic acid and ammonia. It facilitates production of oxaloacetate which is needed for general cellular metabolism. Some malignant cells lose the ability to produce asparagine and so the loss of exogenous sources of asparagine leads to cell death.

Dosage forms of Pegaspargase

FormRouteStrength
Injection, solutionintramuscular; intravenous750[iU]/mL
Liquidintramuscular; intravenous750 unit
Solution for injection/infusionIntramuscular use, Intravenous750 U/ml
Prescription Generics

false

International Brands

Oncaspar

Synonyms

L-asparagine amidohydrolase Putative L-asparaginase precursor

Manufacturers

Baxalta Us Inc.

CAS number

130167-69-0

UNII

7D96IR0PPM

State

liquid

Affected organisms

Humans and other mammals

Indication of Pegaspargase

For treatment of acute lymphoblastic leukemia

Toxicity of Pegaspargase

Adverse effects that occur more than 10% of the time include hepatotoxicity as it is known to increase serum transaminases (ALT, AST). Also known to induce hypersensitivity reactions including anaphylaxis, erythema and bronchospasm.

RX24 Drugs Disclaimer: before buying a Pegaspargase on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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