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Price of Pegaspargase
Oncaspar 750 unit/ml vial
* price without discount in nearest pharmacy. Price may vary.
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Pegaspargase volume of distribution
IV: Adults (asparaginase naive): 2.4 L/m2 ;
Distributes into CSF (reportedly reducing CSF asparagine concentrations to a similar extent as asparaginase
What is Pegaspargase
Pegylated L-asparagine amidohydrolase from E. coli. Pegylation substantially (by a factor of 4) extends the protein half life.
Pegaspargase mechanism of action
Pegaspargase, more effective than asparaginase, converts asparagine to aspartic acid and ammonia. It facilitates production of oxaloacetate which is needed for general cellular metabolism. Some malignant cells lose the ability to produce asparagine and so the loss of exogenous sources of asparagine leads to cell death.
Dosage forms of Pegaspargase
|Injection, solution||intramuscular; intravenous||750 [iU]/mL|
|Liquid||intramuscular; intravenous||750 unit|
|Solution for injection/infusion||Intramuscular use, Intravenous||750 U/ml|
Putative L-asparaginase precursor
Baxalta Us Inc.
Humans and other mammals
Indication of Pegaspargase
For treatment of acute lymphoblastic leukemia
Toxicity of Pegaspargase
Adverse effects that occur more than 10% of the time include hepatotoxicity as it is known to increase serum transaminases (ALT, AST). Also known to induce hypersensitivity reactions including anaphylaxis, erythema and bronchospasm.
Disclaimer: before buying a Pegaspargase on prescription, consult your health care provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.