Save up -80% on Pegaspargase
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Pegaspargase
Oncaspar 750 unit/ml vial
|price without discount in nearest pharmacy. Price may vary.|
We offer free Pegaspargase coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Pegaspargase every time. What are you waiting for? Claim your prescription drug card now!
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Pegaspargase volume of distribution
IV: Adults (asparaginase naive): 2.4 L/m2 ; Distributes into CSF (reportedly reducing CSF asparagine concentrations to a similar extent as asparaginase
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Pegaspargase
Pegylated L-asparagine amidohydrolase from E. coli. Pegylation substantially (by a factor of 4) extends the protein half life.
Pegaspargase mechanism of action
Pegaspargase, more effective than asparaginase, converts asparagine to aspartic acid and ammonia. It facilitates production of oxaloacetate which is needed for general cellular metabolism. Some malignant cells lose the ability to produce asparagine and so the loss of exogenous sources of asparagine leads to cell death.
Dosage forms of Pegaspargase
|Injection, solution||intramuscular; intravenous||750[iU]/mL|
|Liquid||intramuscular; intravenous||750 unit|
|Solution for injection/infusion||Intramuscular use, Intravenous||750 U/ml|
L-asparagine amidohydrolase Putative L-asparaginase precursor
Baxalta Us Inc.
Humans and other mammals
Indication of Pegaspargase
For treatment of acute lymphoblastic leukemia
Toxicity of Pegaspargase
Adverse effects that occur more than 10% of the time include hepatotoxicity as it is known to increase serum transaminases (ALT, AST). Also known to induce hypersensitivity reactions including anaphylaxis, erythema and bronchospasm.
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