Save up -80% on Peginterferon alfa-2b
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Pegintron
|$2,986.98||4 packages (1 vial) 50mcg/0.5ml|
|price without discount in nearest pharmacy. Price may vary.|
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Peginterferon alfa-2b volume of distribution
Peginterferon alfa-2b has a relatively rapid absorption with a half-life of 4.6 hours and a volume of distribution of 0.99L/Kg, which are not significantly different from that of standard interferon alfa-2b, 2.3 hours and ~1.4L/Kg respectively.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Peginterferon alfa-2b
Peginterferon alfa-2b is a covalent conjugate of recombinant alfa-2b interferon with monomethoxy polyethylene glycol (PEG). The average molecular weight of the PEG portion of the molecule is 12,000 daltons. The average molecular weight of the PEG-Intron molecule is approximately 31,000 daltons. The specific activity of peginterferon alfa-2b is approximately 0.7 x 108 IU/mg protein. Interferon alfa-2b is a water-soluble protein with a molecular weight of 19,271 daltons produced by recombinant DNA techniques. It is obtained from the bacterial fermentation of a strain of iEscherichia coli/i bearing a genetically engineered plasmid containing an interferon gene from human leukocytes. The PEG strand protects the molecule in vivo from proteolytic breakdown, substantially increases its in vivo half-life, and reduces immunogenicity by wrapping around and physically hindering access to the protein portion of the molecule.
Peginterferon alfa-2b mechanism of action
Interferon alpha binds to type I interferon receptors (IFNAR1 and IFNAR2c) which, upon dimerization, activate two Jak (Janus kinase) tyrosine kinases (Jak1 and Tyk2). These transphosphorylate themselves and phosphorylate the receptors. The phosphorylated INFAR receptors then bind to Stat1 and Stat2 (signal transducers and activators of transcription)which dimerize and activate multiple (~100) immunomodulatory and antiviral proteins. Interferon alpha binds less stably to type I interferon receptors than interferon beta.
Dosage forms of Peginterferon alfa-2b
|Capsule; powder for solution||oral; subcutaneous|
|Injection, powder, lyophilized, for solution||subcutaneous||120 ug/.5mL|
|Injection, powder, lyophilized, for solution||subcutaneous||150 ug/.5mL|
Merck Canada Inc
Humans and other mammals
Indication of Peginterferon alfa-2b
For the treatment of chronic hepatitis C in patients not previously treated with interferon alpha who have compensated liver disease and are at least 18 years of age.
Toxicity of Peginterferon alfa-2b
Toxicity was generally mild and transient, with grade 1 toxicity occurring in 100% of patients, grade 2 toxicity in 89%, grade 3 toxicity in 58%, and grade 4 toxicity in 17%. Ten of 43 patients available for evaluation had an abnormal neurologic examination. Severe neurotoxicity in the form of spastic diplegia occurred in one patient. In conclusion, IFN alfa therapy is generally well tolerated in children. However, it may rarely be associated with severe toxicity and must be used with caution.
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