Save up -80% on Pegvisomant
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Somavert
|Price with discount in nearest pharmacy. Price may vary.|
We offer free Somavert coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Pegvisomant every time. What are you waiting for? Claim your prescription drug card now!
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Pegvisomant volume of distribution
The mean extent of absorption of a 20-mg subcutaneous dose was 57%, relative to a 10-mg intravenous dose. Distribution The mean apparent volume of distribution of pegvisomant is 7 L (12% coefficient of variation), suggesting that pegvisomant does not distribute extensively into tissues.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Pegvisomant
Pegvisomant is a highly selective growth hormone (GH) receptor antagonist. It is used to treat acromegaly. Unlike dopamine or somatostatin analogs (which inhibit growth hormone secretion), this drug actually blocks the hepatic (GH-mediated) production of insulin like growth factor (IGF-1), which is the main mediator of growth hormone activity.
Pegvisomant mechanism of action
Somavert selectively binds to growth hormone (GH) receptors on cell surfaces, where it blocks the binding of endogenous GH. This leads to the normalization of serum IGF-1 levels.
Dosage forms of Pegvisomant
|Kit; powder for solution||subcutaneous||10 mg|
|Kit; powder for solution||subcutaneous||15 mg|
Pfizer Canada Inc
Humans and other mammals
Indication of Pegvisomant
Pegvisomant is a growth hormone receptor antagonist used for the treatment of acromegaly.
Toxicity of Pegvisomant
PEGv 15 mg every other day was added to lanreotide 120 mg monthly. The patient developed a severe hepatitis five months after starting the combination therapy. Elevated ferritin, iron, and transferrin saturation suggested probable hepatitis due to haemochromatosis. We performed a liver biopsy which showed an acute cholestatic hepatitis consistent with toxic etiology.
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