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RX BIN: 015558
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Penciclovir

Denavir 1% cream



* price without discount in nearest pharmacy. Price may vary.

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Penciclovir volume of distribution

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What is Penciclovir

Penciclovir is a guanine analogue antiviral drug used for the treatment of various herpesvirus infections. It is a nucleoside analogue which exhibits low toxicity and good selectivity. (Wikipedia)

Penciclovir mechanism of action

Penciclovir has i in vitro /i activity against herpes simplex virus types 1 (HSV-1) and 2 (HSV-2). In cells infected with HSV-1 or HSV-2, viral thymidine kinase phosphorylates penciclovir to a monophosphate form. The monophosphate form of the drug is then converted to penciclovir triphosphate by cellular kinases. The intracellular triphosphate of penciclovir is retained i in vitro /i inside HSV-infected cells for 10-20 hours, compared with 0.7-1 hour for acyclovir. i in vitro /i studies show that penciclovir triphosphate selectively inhibits viral DNA polymerase by competing with deoxyguanosine triphosphate. Inhibition of DNA synthesis of virus-infected cells inhibits viral replication. In cells not infected with HSV, DNA synthesis is unaltered. Resistant mutants of HSV can occur from qualitative changes in viral thymidine kinase or DNA polymerase. The most commonly encountered acyclovir-resistant mutants that are deficient in viral thymidine kinase are also resistant to penciclovir.

Dosage forms of Penciclovir

Denavir Cream1%2g Cream$39.00
Denavir Cream1%6g Cream$88.00
Prescription Generics


International Brands



9-(4-hydroxy-3-(hydroxymethyl)butyl)guanine 9-(4-hydroxy-3-hydroxymethylbut-1-yl)-guanine



CAS number






Affected organisms

Herpes simplex virus

Indication of Penciclovir

Used to treat recurrent cold sores on the lips and face from various herpesvirus invections.

Toxicity of Penciclovir

Symptoms of overdose include headache, abdominal pain, increased serum lipase, nausea, dyspepsia, dizziness, and hyperbilirubinemia.

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