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2018 Price of Penicillamine
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Penicillamine volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Penicillamine
Penicillamine is a pharmaceutical of the chelator class. The pharmaceutical form is D-penicillamine, as L-penicillamine is toxic (it inhibits the action of pyridoxine). It is an .-amino acid metabolite of penicillin, although it has no antibiotic properties.
Penicillamine mechanism of action
Penicillamine is a chelating agent recommended for the removal of excess copper in patients with Wilson’s disease. From in vitro studies which indicate that one atom of copper combines with two molecules of penicillamine. Penicillamine also reduces excess cystine excretion in cystinuria. This is done, at least in part, by disulfide interchange between penicillamine and cystine, resulting in formation of penicillamine-cysteine disulfide, a substance that is much more soluble than cystine and is excreted readily. Penicillamine interferes with the formation of cross-links between tropocollagen molecules and cleaves them when newly formed. The mechanism of action of penicillamine in rheumatoid arthritis is unknown although it appears to suppress disease activity. Unlike cytotoxic immunosuppressants, penicillamine markedly lowers IgM rheumatoid factor but produces no significant depression in absolute levels of serum immunoglobulins. Also unlike cytotoxic immunosuppressants which act on both, penicillamine in vitro depresses T-cell activity but not B-cell activity.
Dosage forms of Penicillamine
(.)-penicillamine (S)-2-amino-3-mercapto-3-methylbutanoic acid
Valeant Canada Lp Valeant Canada S.E.C.
Humans and other mammals
Indication of Penicillamine
For treatment of Wilson’s disease, cystinuria and active rheumatoid arthritis.
Toxicity of Penicillamine
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