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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Cuprimine

$31,120.81120 capsules/250 mg
price without discount in nearest pharmacy. Price may vary.

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Penicillamine volume of distribution

Volume of distribution (Vd), 57.0 +/- 9.3 l

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About RX24Drugs

2018 Statistics

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Discount Cards 16,000+


Clients Benefit 29%


Total savings $4,735,080

What is Penicillamine

Penicillamine is a pharmaceutical of the chelator class. The pharmaceutical form is D-penicillamine, as L-penicillamine is toxic (it inhibits the action of pyridoxine). It is an .-amino acid metabolite of penicillin, although it has no antibiotic properties.

Penicillamine mechanism of action

Penicillamine is a chelating agent recommended for the removal of excess copper in patients with Wilson’s disease. From in vitro studies which indicate that one atom of copper combines with two molecules of penicillamine. Penicillamine also reduces excess cystine excretion in cystinuria. This is done, at least in part, by disulfide interchange between penicillamine and cystine, resulting in formation of penicillamine-cysteine disulfide, a substance that is much more soluble than cystine and is excreted readily. Penicillamine interferes with the formation of cross-links between tropocollagen molecules and cleaves them when newly formed. The mechanism of action of penicillamine in rheumatoid arthritis is unknown although it appears to suppress disease activity. Unlike cytotoxic immunosuppressants, penicillamine markedly lowers IgM rheumatoid factor but produces no significant depression in absolute levels of serum immunoglobulins. Also unlike cytotoxic immunosuppressants which act on both, penicillamine in vitro depresses T-cell activity but not B-cell activity.

Dosage forms of Penicillamine

Capsuleoral125 mg
Capsuleoral250 mg
Capsuleoral250 mg/1

Prescription Generics


International Brands



(.)-penicillamine (S)-2-amino-3-mercapto-3-methylbutanoic acid


Valeant Canada Lp Valeant Canada S.E.C.

CAS number






Affected organisms

Humans and other mammals

Indication of Penicillamine

For treatment of Wilson’s disease, cystinuria and active rheumatoid arthritis.

Toxicity of Penicillamine

A serious limitation to therapy in rheumatoid arthritis. A retrospective study of penicillamine toxicity in 156 patients yielded a high incidence of toxic reaction (62%), necessitating discontinuation of the drug therapy in 36% of the patients.

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