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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Pentobarbital

Nembutal sodium 50 mg/ml via

$20.65

ml

* price without discount in nearest pharmacy. Price may vary.

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Pentobarbital volume of distribution

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What is Pentobarbital

A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236)

Pentobarbital mechanism of action

Pentobarbital binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged. All of these effects are associated with marked decreases in GABA-sensitive neuronal calcium conductance (gCa). The net result of barbiturate action is acute potentiation of inhibitory GABAergic tone. Barbiturates also act through potent (if less well characterized) and direct inhibition of excitatory AMPA-type glutamate receptors, resulting in a profound suppression of glutamatergic neurotransmission.

Dosage forms of Pentobarbital

FormRouteStrength
Injectionintramuscular; intravenous50 mg/mL
Capsuleoral100 mg
Solutionintramuscular; intravenous50 mg
Prescription Generics

true

International Brands

Nembutal Sodium

Synonyms

5-Ethyl-5-(1-methyl-butyl)-pyrimidine-2,4,6-trione 5-Ethyl-5-(1-methylbutyl)-2,4,6(1H,3H,5H)-pyrimidinetrione

Manufacturers

Oak Pharmaceuticals, Inc. (Subsidiary of Akorn, Inc.)

CAS number

76-74-4

UNII

I4744080IR

State

solid

Affected organisms

Humans and other mammals

Indication of Pentobarbital

For the short-term treatment of insomnia.

Toxicity of Pentobarbital

Symptoms of an overdose typically include sluggishness, incoordination, difficulty in thinking, slowness of speech, faulty judgment, drowsiness or coma, shallow breathing, staggering, and in severe cases coma and death.

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