Save up -80% on Pentobarbital
Note: this is a drug discount program, not an insurance plan.
2018 Price of Pentobarbital
Nembutal sodium 50 mg/ml via
* price without discount in nearest pharmacy. Price may vary.
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Pentobarbital volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Pentobarbital
A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236)
Pentobarbital mechanism of action
Pentobarbital binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged. All of these effects are associated with marked decreases in GABA-sensitive neuronal calcium conductance (gCa). The net result of barbiturate action is acute potentiation of inhibitory GABAergic tone. Barbiturates also act through potent (if less well characterized) and direct inhibition of excitatory AMPA-type glutamate receptors, resulting in a profound suppression of glutamatergic neurotransmission.
Dosage forms of Pentobarbital
|Injection||intramuscular; intravenous||50 mg/mL|
|Solution||intramuscular; intravenous||50 mg|
Oak Pharmaceuticals, Inc. (Subsidiary of Akorn, Inc.)
Humans and other mammals
Toxicity of Pentobarbital
Symptoms of an overdose typically include sluggishness, incoordination, difficulty in thinking, slowness of speech, faulty judgment, drowsiness or coma, shallow breathing, staggering, and in severe cases coma and death.
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