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RX BIN: 015558
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Pentostatin

Nipent 10 mg vial



* price without discount in nearest pharmacy. Price may vary.

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Pentostatin volume of distribution

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What is Pentostatin

A potent inhibitor of adenosine deaminase. The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity.

Pentostatin mechanism of action

Pentostatin is a potent transition state inhibitor of adenosine deaminase (ADA), the greatest activity of which is found in cells of the lymphoid system. T-cells have higher ADA activity than B-cells, and T-cell malignancies have higher activity than B-cell malignancies. The cytotoxicity that results from prevention of catabolism of adenosine or deoxyadenosine is thought to be due to elevated intracellular levels of dATP, which can block DNA synthesis through inhibition of ribonucleotide reductase. Intracellular activation results in incorporation into DNA as a false purine base. An additional cytotoxic effect is related to its incorporation into RNA. Cytotoxicity is cell cycle phase-specific (S-phase).

Dosage forms of Pentostatin

Injection, powder, lyophilized, for solutionintravenous2 mg/mL
Powder for solutionintravenous10 mg
Prescription Generics


International Brands



Co-vidarabine Nipent


Hospira, Inc.

CAS number






Affected organisms

Humans and other mammals

Indication of Pentostatin

For the treatment of hairy cell leukaemia refractory to alpha interferon.

Toxicity of Pentostatin

LD sub50 /sub=128 mg/kg (mouse), side effects include lethargy, rash, fatigue, nausea and myelosuppression.

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