Save up -80% on Pentostatin
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Pentostatin
Nipent 10 mg vial
|price without discount in nearest pharmacy. Price may vary.|
We offer free Pentostatin coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your discount card in most local pharmacies to get a discount on Pentostatin every time. What are you waiting for? Claim your prescription drug card now!
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Pentostatin volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Pentostatin
A potent inhibitor of adenosine deaminase. The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity.
Pentostatin mechanism of action
Pentostatin is a potent transition state inhibitor of adenosine deaminase (ADA), the greatest activity of which is found in cells of the lymphoid system. T-cells have higher ADA activity than B-cells, and T-cell malignancies have higher activity than B-cell malignancies. The cytotoxicity that results from prevention of catabolism of adenosine or deoxyadenosine is thought to be due to elevated intracellular levels of dATP, which can block DNA synthesis through inhibition of ribonucleotide reductase. Intracellular activation results in incorporation into DNA as a false purine base. An additional cytotoxic effect is related to its incorporation into RNA. Cytotoxicity is cell cycle phase-specific (S-phase).
Dosage forms of Pentostatin
|Injection, powder, lyophilized, for solution||intravenous||2 mg/mL|
|Powder for solution||intravenous||10 mg|
Humans and other mammals
Indication of Pentostatin
For the treatment of hairy cell leukaemia refractory to alpha interferon.
Toxicity of Pentostatin
LD sub50 /sub=128 mg/kg (mouse), side effects include lethargy, rash, fatigue, nausea and myelosuppression.
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