Save up -80% on Pentostatin

Note: this is a drug discount program, not an insurance plan.
RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Pentostatin

Nipent 10 mg vial

$1891.31vial
price without discount in nearest pharmacy. Price may vary.

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We offer free Pentostatin coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your discount card in most local pharmacies to get a discount on Pentostatin every time. What are you waiting for? Claim your prescription drug card now!

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Pentostatin volume of distribution

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2018 Statistics

discount card

Discount Cards 16,000+

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Clients Benefit 29%

savings

Total savings $4,735,080

What is Pentostatin

A potent inhibitor of adenosine deaminase. The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity.

Pentostatin mechanism of action

Pentostatin is a potent transition state inhibitor of adenosine deaminase (ADA), the greatest activity of which is found in cells of the lymphoid system. T-cells have higher ADA activity than B-cells, and T-cell malignancies have higher activity than B-cell malignancies. The cytotoxicity that results from prevention of catabolism of adenosine or deoxyadenosine is thought to be due to elevated intracellular levels of dATP, which can block DNA synthesis through inhibition of ribonucleotide reductase. Intracellular activation results in incorporation into DNA as a false purine base. An additional cytotoxic effect is related to its incorporation into RNA. Cytotoxicity is cell cycle phase-specific (S-phase).

Dosage forms of Pentostatin

FormRouteStrength
Injection, powder, lyophilized, for solutionintravenous2 mg/mL
Powder for solutionintravenous10 mg

Prescription Generics

false

International Brands

Nipent

Synonyms

Co-vidarabine Nipent

Manufacturers

Hospira, Inc.

CAS number

53910-25-1

UNII

395575MZO7

State

solid

Affected organisms

Humans and other mammals

Indication of Pentostatin

For the treatment of hairy cell leukaemia refractory to alpha interferon.

Toxicity of Pentostatin

LD sub50 /sub=128 mg/kg (mouse), side effects include lethargy, rash, fatigue, nausea and myelosuppression.

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