Save up -80% on Pentostatin
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2018 Price of Pentostatin
Nipent 10 mg vial
* price without discount in nearest pharmacy. Price may vary.
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Pentostatin volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Pentostatin
A potent inhibitor of adenosine deaminase. The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity.
Pentostatin mechanism of action
Pentostatin is a potent transition state inhibitor of adenosine deaminase (ADA), the greatest activity of which is found in cells of the lymphoid system. T-cells have higher ADA activity than B-cells, and T-cell malignancies have higher activity than B-cell malignancies. The cytotoxicity that results from prevention of catabolism of adenosine or deoxyadenosine is thought to be due to elevated intracellular levels of dATP, which can block DNA synthesis through inhibition of ribonucleotide reductase. Intracellular activation results in incorporation into DNA as a false purine base. An additional cytotoxic effect is related to its incorporation into RNA. Cytotoxicity is cell cycle phase-specific (S-phase).
Dosage forms of Pentostatin
|Injection, powder, lyophilized, for solution||intravenous||2 mg/mL|
|Powder for solution||intravenous||10 mg|
Humans and other mammals
Indication of Pentostatin
For the treatment of hairy cell leukaemia refractory to alpha interferon.
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