Save up -80% on Pentoxifylline
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Trental
|price without discount in nearest pharmacy. Price may vary.|
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Pentoxifylline volume of distribution
Plasma clearance was 1333 +/- 481 ml/min and the volume of distribution was 168 +/- 82.3 l. Cumulation of pentoxifylline in plasma after repeated dosing was minimal.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Pentoxifylline
A methylxanthine derivative that inhibits phosphodiesterase and affects blood rheology. It improves blood flow by increasing erythrocyte and leukocyte flexibility. It also inhibits platelet aggregation. Pentoxifylline modulates immunologic activity by stimulating cytokine production.
Pentoxifylline mechanism of action
Pentoxifylline inhibits erythrocyte phosphodiesterase, resulting in an increase in erythrocyte cAMP activity. Subsequently, the erythrocyte membrane becomes more resistant to deformity. Along with erythrocyte activity, pentoxifylline also decreases blood viscosity by reducing plasma fibrinogen concentrations and increasing fibrinolytic activity. It is also a non selective adenosine receptor antagonist.
Dosage forms of Pentoxifylline
|Tablet, extended release||oral||400 mg/1|
|Tablet, film coated, extended release||oral||400 mg/1|
Alvix Laboratories, LLC
Humans and other mammals
Indication of Pentoxifylline
For the treatment of patients with intermittent lameness or immobility arising from chronic occlusive arterial disease of the limbs.
Toxicity of Pentoxifylline
LDsub50/sub=1385 mg/kg(orally in mice)
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