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RX BIN: 015558
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Pergolide

Pergolide mesylate 100% powder



* price without discount in nearest pharmacy. Price may vary.

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Pergolide volume of distribution

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What is Pergolide

Pergolide is a long-acting dopamine agonist approved in 1982 for the treatment of Parkinsons Disease. It is an ergot derivative that acts on the dopamine D2 and D3, alpha2- and alpha1-adrenergic, and 5-hydroxytryptamine (5-HT) receptors. It was indicated as adjunct therapy with levodopa/carbidopa in the symptomatic treatment of parkinsonian syndrome. It was later found that pergolide increased the risk of cardiac valvulopathy. The drug was withdrawn from the US market in March 2007 and from the Canadian market in August 2007.

Pergolide mechanism of action

The dopamine D sub2 /sub receptor is a 7-transmembrane G-protein coupled receptor associated with G subi /sub proteins. In lactotrophs, stimulation of dopamine D sub2 /sub receptor causes inhibition of adenylyl cyclase, which decreases intracellular cAMP concentrations and blocks IP3-dependent release of Ca sup2+ /sup from intracellular stores. Decreases in intracellular calcium levels may also be brought about via inhibition of calcium influx through voltage-gated calcium channels, rather than via inhibition of adenylyl cyclase. Additionally, receptor activation blocks phosphorylation of p42/p44 MAPK and decreases MAPK/ERK kinase phosphorylation. Inhibition of MAPK appears to be mediated by c-Raf and B-Raf-dependent inhibition of MAPK/ERK kinase. Dopamine-stimulated growth hormone release from the pituitary gland is mediated by a decrease in intracellular calcium influx through voltage-gated calcium channels rather than via adenylyl cyclase inhibition. Stimulation of dopamine D sub2 /sub receptors in the nigrostriatal pathway leads to improvements in coordinated muscle activity in those with movement disorders.

Dosage forms of Pergolide

Tabletoral0.05 mg
Tabletoral0.25 mg
Tabletoral1 mg
Prescription Generics


International Brands

Permax Tab 0.05mg


Pergolida Pergolide Mesylate


Eli Lilly Canada Inc

CAS number






Affected organisms

Humans and other mammals

Indication of Pergolide

Indicated as adjunctive treatment to levodopa/carbidopa in the management of the signs and symptoms of Parkinson‘s disease. It was withdrawn from the US and Canadian markets in 2007 due to an increased risk of cardiac valvulopathy.

Toxicity of Pergolide

Oral, rat LD sub50 /sub: 15 mg/kg. Symptoms of overdose include nausea, vomiting, convulsions, decreased blood pressure, and CNS stimulation.

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