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Price of Perphenazine
Perphenazine 4 mg tablet
* price without discount in nearest pharmacy. Price may vary.
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Perphenazine volume of distribution
What is Perphenazine
An antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine. (PubChem)
Perphenazine mechanism of action
Binds to the dopamine D1 and dopamine D2 receptors and inhibits their activity. The mechanism of the anti-emetic effect is due predominantly to blockage of the dopamine D2 neurotransmitter receptors in the chemoreceptor trigger zone and vomiting centre. Perphenazine also binds the alpha andrenergic receptor. This receptor’s action is mediated by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Dosage forms of Perphenazine
Apo Peram Tab 2-25
Humans and other mammals
Indication of Perphenazine
For use in the management of the manifestations of psychotic disorders and for the control of severe nausea and vomiting in adults.
Toxicity of Perphenazine
Symptoms of overdose include stupor or coma, and children may have convulsive seizures. Signs of arousal may not occur for 48 hours. Oral LDsub50/sub=318 mg/kg (rat); IPR LDsub50/sub=64 mg/kg (mouse)
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