Save up -80% on Pethidine

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RX BIN: 015558
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Pethidine

Meperidine Hydrochloride 75 mg/ml



* price without discount in nearest pharmacy. Price may vary.

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Pethidine volume of distribution

Meperidine crosses the placenta and is distributed into breast milk.

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What is Pethidine

A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration.

Pethidine mechanism of action

Meperidine is primarily a kappa-opiate receptor agonist and also has local anesthetic effects. Meperidine has more affinity for the kappa-receptor than morphine. Opiate receptors are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline is inhibited. Opioids also inhibit the release of vasopressin, somatostatin, insulin and glucagon. Opioids close N-type voltage-operated calcium channels (OP2-receptor agonist) and open calcium-dependent inwardly rectifying potassium channels (OP3 and OP1 receptor agonist). This results in hyperpolarization and reduced neuronal excitability.

Dosage forms of Pethidine

Form Route Strength
Injection, solution intramuscular; intravenous; subcutaneous 100 mg/2mL
Injection, solution intramuscular; intravenous; subcutaneous 100 mg/mL
Injection, solution intramuscular; intravenous; subcutaneous 25 mg/mL
Prescription Generics


International Brands



Isonipecaine Meperidine


Physicians Total Care, Inc.

CAS number






Affected organisms

Humans and other mammals

Indication of Pethidine

Used to control moderate to severe pain.

Toxicity of Pethidine

RX24 Drugs Disclaimer: before buying a Pethidine on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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