Save up -80% on Pethidine
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Pethidine
Meperidine Hydrochloride 75 mg/ml
|price without discount in nearest pharmacy. Price may vary.|
We offer free Pethidine coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Pethidine every time. What are you waiting for? Claim your prescription drug card now!
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Pethidine volume of distribution
Meperidine crosses the placenta and is distributed into breast milk.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Pethidine
A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration.
Pethidine mechanism of action
Meperidine is primarily a kappa-opiate receptor agonist and also has local anesthetic effects. Meperidine has more affinity for the kappa-receptor than morphine. Opiate receptors are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline is inhibited. Opioids also inhibit the release of vasopressin, somatostatin, insulin and glucagon. Opioids close N-type voltage-operated calcium channels (OP2-receptor agonist) and open calcium-dependent inwardly rectifying potassium channels (OP3 and OP1 receptor agonist). This results in hyperpolarization and reduced neuronal excitability.
Dosage forms of Pethidine
|Injection, solution||intramuscular; intravenous; subcutaneous||100 mg/2mL|
|Injection, solution||intramuscular; intravenous; subcutaneous||100 mg/mL|
|Injection, solution||intramuscular; intravenous; subcutaneous||25 mg/mL|
Physicians Total Care, Inc.
Humans and other mammals
Indication of Pethidine
Used to control moderate to severe pain.
Toxicity of Pethidine
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