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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Nardil

$31.090 tablets/15 mg
Price with discount in nearest pharmacy. Price may vary.

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Phenelzine volume of distribution

Phenelzine induced a type II spectral change when combined with oxidized cytochrome P-450 with a Ks value of 0.4 mM. The administration of one dose of 50 mg X kg-1 of phenelzine sulfate concomitantly with 50 mg X kg-1 of antipyrine resulted in a significant decrease of the serum elimination of antipyrine. The serum half-life, apparent volume of distribution, and total body clearance of antipyrine were modified to 3.6 h, 294.1 mL X kg-1, and 56.8 mL X h-1 X kg-1, respectively, from 1.5 h, 666.7 mL X kg-1, and 312.5 mL X h-1 X kg-1 when antipyrine was administered alone. It is concluded that the inhibitory effect of phenelzine on the microsomal oxidative reactions of rat liver is related to its interaction with cytochrome P-450.

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2018 Statistics

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What is Phenelzine

An irreversible non-selective inhibitor of monoamine oxidase. May be used to treat major depressive disorder.

Phenelzine mechanism of action

Although the exact mechanism of action has not been determined, it appears that the irreversible, nonselective inhibition of MAO by phenelzine relieves depressive symptoms by causing an increase in the levels of serotonin, norepinephrine, and dopamine in the neuron.

Dosage forms of Phenelzine

Tabletoral15 mg
Tablet, film coatedoral15 mg/1
Tabletoral15 mg/1

Prescription Generics


International Brands



Alazine Fenelzina


Parke Davis Div Of Pfizer Inc

CAS number






Affected organisms

Humans and other mammals

Indication of Phenelzine

For the treatment of major depressive disorder. Has also been used with some success in the management of bulimia nervosa.

Toxicity of Phenelzine

Symptoms of overdose include drowsiness, dizziness, faintness, irritability, hyperactivity, agitation, severe headache, hallucinations, trismus, opisthotonos, convulsions and coma, rapid and irregular pulse, hypertension, hypotension and vascular collapse, precordial pain, respiratory depression and failure, hyperpyrexia, diaphoresis, and cool, clammy skin. Hypertensive crisis may occur with the ingestion of tyramine-rich foods such as cured meats, poultry or fish, aged cheeses, concentrated soy products, tap beer and wine, yeast extracts, broad bean pods and fava beans and sauerkraut.

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