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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Penicillin V Potassium

$10.7228 tablets/500mg
Price with discount in nearest pharmacy. Price may vary.

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Phenoxymethylpenicillin volume of distribution

Phenoxymethyl penicillin (penicillin V) was administered intravenously (i.v.) and orally to pre-ruminant calves and the distribution and elimination kinetics, as well as the oral bioavailability, were determined. After i.v. injection, the drug was distributed rapidly in the body, the elimination half-life (t1/2 beta) was 34 min and the apparent volume of distribution at steady-state (Vd ss) was 0.30 l/kg. Mean peak serum drug concentrations were directly related to the oral dose administered, i.e. 0.22 microgram/ml, 1.06 micrograms/ml and 2.14 micrograms/ml after dosing at 10, 20 and 40 mg/kg, respectively.

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What is Phenoxymethylpenicillin

Phenoxymethylpenicillin (Penicillin V) is narrow spectrum antibiotic used to treat mild to moderate infections caused by susceptible bacteria. It is a natural penicillin antibiotic that is administered orally. Penicillin V may also be used in some cases as prophylaxis against susceptible organisms. Natural penicillins are considered the drugs of choice for several infections caused by susceptible gram positive aerobic organisms, such as iStreptococcus pneumoniae /i, groups A, B, C and G streptococci, nonenterococcal group D streptococci, viridans group streptococci, and non-penicillinase producing staphylococcus. Aminoglycosides may be added for synergy against group B streptococcus ( iS. agalactiae /i), iS. viridans /i, and iEnterococcus faecalis /i. The natural penicillins may also be used as first or second line agents against susceptible gram positive aerobic bacilli such as iBacillus anthracis /i, iCorynebacterium diphtheriae /i, and iErysipelothrix rhusiopathiae /i. Natural penicillins have limited activity against gram negative organisms; however, they may be used in some cases to treat infections caused by iNeisseria meningitidis /i and iPasteurella /i. They are not generally used to treat anaerobic infections. Resistance patterns, susceptibility and treatment guidelines vary across regions.

Phenoxymethylpenicillin mechanism of action

By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, Penicillin V inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that Penicillin V interferes with an autolysin inhibitor.

Dosage forms of Phenoxymethylpenicillin

FormRouteStrength
Powder for solutionoral200000 unit
Powder for solutionoral480000 unit
Tabletoral400000 unit

Prescription Generics

true

International Brands

Apo Pen Vk

Synonyms

(2S,5R,6R)-3,3-DIMETHYL-7-oxo-6-(2-phenoxyacetamido)-4-thia-1- azabicyclo(3.2.0)heptane-2-carboxylic acid (2S,5R,6R)-3,3-Dimethyl-7-oxo-6-((phenoxyacetyl)amino)-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid

Manufacturers

Apotex Inc

CAS number

87-08-1

UNII

Z61I075U2W

State

solid

Affected organisms

Bacteria

Indication of Phenoxymethylpenicillin

For the treatment of mild to moderately severe infections (e.g. dental infection, infections in the heart, middle ear infections, rheumatic fever, scarlet fever, skin infections, upper and lower respiratory tract infections) due to microorganisms

Toxicity of Phenoxymethylpenicillin

LD sub50 /sub 1040 mg/kg (Orally in rats with Sodium salt); Nausea, vomiting, stomach pain, diarrhea, and, in rare cases, major motor seizures

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