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RX BIN: 015558
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Phenylbutazone

Phenylbutazone powder



* price without discount in nearest pharmacy. Price may vary.

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Phenylbutazone volume of distribution

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What is Phenylbutazone

A drug that has anti-inflammatory, antipyretic, and analgesic activities. It is especially effective in the treatment of ankylosing spondylitis. It also is useful in rheumatoid arthritis and Reiter #39;s syndrome (investigational indication). Although phenylbutazone is effective in gouty arthritis, risk/benefit considerations indicate that this drug should not be employed for this disease. (From AMA Drug Evaluations Annual, 1994, p1822)

Phenylbutazone mechanism of action

Phenylbutazone binds to and inactivates prostaglandin H synthase and prostacyclin synthase through peroxide (H2O2) mediated deactivation. The reduced production of prostaglandin leads to reduced inflammation of the surrounding tissues.

Dosage forms of Phenylbutazone

Tabletoral100 mg
Prescription Generics


International Brands

Alka Phenyl Tab


3,5-Dioxo-1,2-diphenyl-4-n-butylpyrazolidine 4-BUTYL-1,2-diphenyl-pyrazolidine-3,5-dione


Duchesnay Inc

CAS number






Affected organisms

Humans and other mammals

Indication of Phenylbutazone

For the treatment of backache and ankylosing spondylitis

Toxicity of Phenylbutazone

Oral, LDsub50/sub = 238 mg/kg (mouse); Oral, LDsub50/sub = 781 mg/kg (rabbit); Oral, LDsub50/sub = 245 mg/kg (rat); Oral, LDsub50/sub = 375 mg/kg (rat)

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