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Price of Phenylbutazone
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Phenylbutazone volume of distribution
What is Phenylbutazone
A drug that has anti-inflammatory, antipyretic, and analgesic activities. It is especially effective in the treatment of ankylosing spondylitis. It also is useful in rheumatoid arthritis and Reiter #39;s syndrome (investigational indication). Although phenylbutazone is effective in gouty arthritis, risk/benefit considerations indicate that this drug should not be employed for this disease. (From AMA Drug Evaluations Annual, 1994, p1822)
Phenylbutazone mechanism of action
Phenylbutazone binds to and inactivates prostaglandin H synthase and prostacyclin synthase through peroxide (H2O2) mediated deactivation. The reduced production of prostaglandin leads to reduced inflammation of the surrounding tissues.
Dosage forms of Phenylbutazone
Alka Phenyl Tab
Humans and other mammals
Indication of Phenylbutazone
For the treatment of backache and ankylosing spondylitis
Toxicity of Phenylbutazone
Oral, LDsub50/sub = 238 mg/kg (mouse); Oral, LDsub50/sub = 781 mg/kg (rabbit); Oral, LDsub50/sub = 245 mg/kg (rat); Oral, LDsub50/sub = 375 mg/kg (rat)
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