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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Phenylephrine

Mydfrin 2.5 % Solution

$1.09

ml

* price without discount in nearest pharmacy. Price may vary.

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Phenylephrine volume of distribution

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What is Phenylephrine

Phenylephrine is a sympathomimetic amine that acts predominantly on alpha;-adrenergic receptors. It is mainly used to treat nasal congestion, but may also be useful in treating hypotension and shock, hypotension during spinal anaesthesia, prolongation of spinal anaesthesia, paroxysmal supraventricular tachycardia, symptomatic relief of external or internal hemorrhoids, and to increase blood pressure as an aid in the diagnosis of heart murmurs.

Phenylephrine mechanism of action

In general, alpha; sub 1 /sub -adrenergic receptors mediate contraction and hypertrophic growth of smooth muscle cells. alpha; sub 1 /sub -receptors are 7-transmembrane domain receptors coupled to G proteins, G sub q/11 /sub . Three alpha; sub 1 /sub -receptor subtypes, which share approximately 75% homology in their transmembrane domains, have been identified: alpha; sub 1A /sub (chromosome 8), alpha; sub 1B /sub (chromosome 5), and alpha; sub 1D /sub (chromosome 20). Phenylephrine appears to act similarly on all three receptor subtypes. All three receptor subtypes appear to be involved in maintaining vascular tone. The alpha; sub 1A /sub -receptor maintains basal vascular tone while the alpha; sub 1B /sub -receptor mediates the vasocontrictory effects of exogenous alpha; sub 1 /sub -agonists. Activation of the alpha; sub 1 /sub -receptor activates G sub q /sub -proteins, which results in intracellular stimulation of phospholipases C, A sub 2 /sub , and D. This results in mobilization of Ca sup 2+ /sup from intracellular stores, activation of mitogen-activated kinase and PI sub 3 /sub kinase pathways and subsequent vasoconstriction. Phenylephrine produces its local and systemic actions by acting on alpha; sub 1 /sub -adrenergic receptors peripheral vascular smooth muscle. Stimulation of the alpha; sub 1 /sub -adrenergic receptors results in contraction arteriolar smooth muscle in the periphery. Phenylephrine decreases nasal congestion by acting on alpha; sub 1 /sub -adrenergic receptors in the arterioles of the nasal mucosa to produce constriction; this leads to decreased edema and increased drainage of the sinus cavities.

Dosage forms of Phenylephrine

DrugDosageQuantityPrice
Dristan Nasal Mist0.05/0.02%30mL Nasal Spray$29.00
Prescription Generics

false

International Brands

4 Way Fast Acting

Synonyms

(-)-m-Hydroxy-alpha-(methylaminomethyl)benzyl alcohol (-)-m-Hydroxy–(methylaminomethyl)benzyl alcohol

Manufacturers

Novartis Consumer Health, Inc.

CAS number

59-42-7

UNII

1WS297W6MV

State

solid

Affected organisms

Humans and other mammals

Indication of Phenylephrine

Phenylephrine is mainly used to treat nasal congestion, but may also be useful in treating hypotension and shock, hypotension during spinal anaesthesia, prolongation of spinal anaesthesia, paroxysmal supraventricular tachycardia, symptomatic relief of external or internal hemorrhoids, and to increase blood pressure as an aid in the diagnosis of heart murmurs.

Toxicity of Phenylephrine

RX24 Drugs Disclaimer: before buying a Phenylephrine on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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