Save up -80% on Phylloquinone
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2018 Price of Phylloquinone
Vitamin K1 10 mg/ml
* price without discount in nearest pharmacy. Price may vary.
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Phylloquinone volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Phylloquinone
Phylloquinone is often called vitamin K1. It is a fat-soluble vitamin that is stable to air and moisture but decomposes in sunlight. It is found naturally in a wide variety of green plants. Phylloquinone is also an antidote for coumatetralyl. Vitamin K is needed for the posttranslational modification of certain proteins, mostly required for blood coagulation.
Phylloquinone mechanism of action
Vitamin K is an essential cofactor for the gamma-carboxylase enzymes which catalyze the posttranslational gamma-carboxylation of glutamic acid residues in inactive hepatic precursors of coagulation factors II (prothrombin), VII, IX and X. Gamma-carboxylation converts these inactive precursors into active coagulation factors which are secreted by hepatocytes into the blood. Supplementing with Phylloquinone results in a relief of vitamin K deficiency symptoms which include easy bruisability, epistaxis, gastrointestinal bleeding, menorrhagia and hematuria.
Dosage forms of Phylloquinone
|Injection, powder, lyophilized, for solution||intravenous|
Aventis Pharma Inc
Humans and other mammals
Indication of Phylloquinone
For the treatment of haemorrhagic conditions in infants, antidote for coumarin anticoagulants in hypoprothrombinaemia.
Toxicity of Phylloquinone
The intravenous LD sub 50 /sub of phylloquinone in the mouse is 41.5 and 52 mL/kg for the 0.2% and 1% concentrations, respectively.
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