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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Phylloquinone

Vitamin K1 10 mg/ml

$2.76

ml

* price without discount in nearest pharmacy. Price may vary.

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Phylloquinone volume of distribution

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What is Phylloquinone

Phylloquinone is often called vitamin K1. It is a fat-soluble vitamin that is stable to air and moisture but decomposes in sunlight. It is found naturally in a wide variety of green plants. Phylloquinone is also an antidote for coumatetralyl. Vitamin K is needed for the posttranslational modification of certain proteins, mostly required for blood coagulation.

Phylloquinone mechanism of action

Vitamin K is an essential cofactor for the gamma-carboxylase enzymes which catalyze the posttranslational gamma-carboxylation of glutamic acid residues in inactive hepatic precursors of coagulation factors II (prothrombin), VII, IX and X. Gamma-carboxylation converts these inactive precursors into active coagulation factors which are secreted by hepatocytes into the blood. Supplementing with Phylloquinone results in a relief of vitamin K deficiency symptoms which include easy bruisability, epistaxis, gastrointestinal bleeding, menorrhagia and hematuria.

Dosage forms of Phylloquinone

FormRouteStrength
Liquidintravenous
Injection, powder, lyophilized, for solutionintravenous
Tabletoral5 mg/1
Prescription Generics

false

International Brands

M.V.I. Paediatric

Synonyms

2-Methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-1,4-naphthalenedione 2-Methyl-3-((2e)-3,7,11,15-tetramethyl-2-hexadecenyl)naphthoquinone

Manufacturers

Aventis Pharma Inc

CAS number

84-80-0

UNII

S5Z3U87QHF

State

liquid

Affected organisms

Humans and other mammals

Indication of Phylloquinone

For the treatment of haemorrhagic conditions in infants, antidote for coumarin anticoagulants in hypoprothrombinaemia.

Toxicity of Phylloquinone

The intravenous LD sub 50 /sub of phylloquinone in the mouse is 41.5 and 52 mL/kg for the 0.2% and 1% concentrations, respectively.

RX24 Drugs Disclaimer: before buying a Phylloquinone on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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