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Price of Pimecrolimus
Elidel 1% cream
* price without discount in nearest pharmacy. Price may vary.
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Pimecrolimus volume of distribution
What is Pimecrolimus
Pimecrolimus is an immunomodulating agent used in the treatment of atopic dermatitis (eczema). It is currently available as a topical cream, once marketed by Novartis, (however Galderma will be promoting the molecule in Canada in early 2007) under the trade name Elidel. (Wikipedia)
Pimecrolimus mechanism of action
Pimecrolimus binds with high affinity to macrophilin-12 (FKBP-12) and inhibits the calcium-dependent phosphatase, calcineurin. As a consequence, it inhibits T cell activation by blocking the transcription of early cytokines. In particular, pimecrolimus inhibits at nanomolar concentrations Interleukin-2 and interferon gamma (Th1-type) and Interleukin-4 and Interleukin-10 (Th2-type) cytokine synthesis in human T cells. Also, pimecrolimus prevents the release of inflammatory cytokines and mediators from mast cells in vitro after stimulation by antigen/lgE.
Dosage forms of Pimecrolimus
Physicians Total Care, Inc.
Humans and other mammals
Indication of Pimecrolimus
For treatment of mild to moderate atopic dermatitis.
Toxicity of Pimecrolimus
Side effects include burning sensation, irritation, pruritus, erythema, and skin infections, at the application site.
Disclaimer: before buying a Pimecrolimus on prescription, consult your health care provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.