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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Piperazine

Desipramine HCl 50 mg tablet

$1.64

tablet

* price without discount in nearest pharmacy. Price may vary.

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Piperazine volume of distribution

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What is Piperazine

Piperazine is an organic compound that consists of a six-membered ring containing two opposing nitrogen atoms. Piperazine exists as small alkaline deliquescent crystals with a saline taste. Piperazine was introduced to medicine as a solvent for uric acid. When taken into the body the drug is partly oxidized and partly eliminated unchanged. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Piperazine was first introduced as an anthelmintic in 1953. A large number of piperazine compounds have anthelmintic action. Their mode of action is generally by paralysing parasites, which allows the host body to easily remove or expel the invading organism.

Piperazine mechanism of action

Piperazine is a GABA receptor agonist. Piperzine binds directly and selectively to muscle membrane GABA receptors, presumably causing hyperpolarization of nerve endings, resulting in flaccid paralysis of the worm. While the worm is paralyzed, it is dislodged from the intestinal lumen and expelled live from the body by normal intestinal peristalsis.

Dosage forms of Piperazine

FormRouteStrength
Powder for solutionoral2 g
Powderoral2 g
Suspensionoral600 mg
Prescription Generics

false

International Brands

Entacyl Granules

Synonyms

Diethylenediamine Piperazidine

Manufacturers

Shire Pharma Canada Ulc

CAS number

110-85-0

UNII

1RTM4PAL0V

State

solid

Affected organisms

Parasitic nematodes and other roundworms

Indication of Piperazine

Used as alternative treatment for ascariasis caused by iAscaris lumbricoides /i (roundworm) and enterobiasis (oxyuriasis) caused by iEnterobius vermicularis /i (pinworm). It is also used to treat partial intestinal obstruction by the common roundworm, a condition primarily occurring in children.

Toxicity of Piperazine

LD sub50 /sub = 5 g/kg (Human, oral). Symptoms of overdose include muscle fatigue, seizures, and difficulty breathing.

RX24 Drugs Disclaimer: before buying a Piperazine on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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