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Price of Piperazine
Desipramine HCl 50 mg tablet
* price without discount in nearest pharmacy. Price may vary.
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Piperazine volume of distribution
What is Piperazine
Piperazine is an organic compound that consists of a six-membered ring containing two opposing nitrogen atoms. Piperazine exists as small alkaline deliquescent crystals with a saline taste.
Piperazine was introduced to medicine as a solvent for uric acid. When taken into the body the drug is partly oxidized and partly eliminated unchanged. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful.
Piperazine was first introduced as an anthelmintic in 1953. A large number of piperazine compounds have anthelmintic action. Their mode of action is generally by paralysing parasites, which allows the host body to easily remove or expel the invading organism.
Piperazine mechanism of action
Piperazine is a GABA receptor agonist. Piperzine binds directly and selectively to muscle membrane GABA receptors, presumably causing hyperpolarization of nerve endings, resulting in flaccid paralysis of the worm. While the worm is paralyzed, it is dislodged from the intestinal lumen and expelled live from the body by normal intestinal peristalsis.
Dosage forms of Piperazine
|Powder for solution||oral||2 g|
Shire Pharma Canada Ulc
Parasitic nematodes and other roundworms
Indication of Piperazine
Used as alternative treatment for ascariasis caused by iAscaris lumbricoides /i (roundworm) and enterobiasis (oxyuriasis) caused by iEnterobius vermicularis /i (pinworm). It is also used to treat partial intestinal obstruction by the common roundworm, a condition primarily occurring in children.
Toxicity of Piperazine
LD sub50 /sub = 5 g/kg (Human, oral). Symptoms of overdose include muscle fatigue, seizures, and difficulty breathing.
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