Save up -80% on Pirfenidone
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2018 Price of Pirfenidone
* price without discount in nearest pharmacy. Price may vary.
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Pirfenidone volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Pirfenidone
Pirfenidone is an orally active small molecule drug that may inhibit collagen synthesis, down regulate production of multiple cytokines and block fibroblast proliferation and stimulation in response to cytokines. Pirfenidone has demonstrated activity in multiple fibrotic conditions, including those of the lung, kidney and liver. It is being investigated by InterMune.
Pirfenidone mechanism of action
Pirfenidone is an orally active, small molecule that shows a wide range of biologic activity. In vitro evidence has shown that pirfenidone inhibits collagen synthesis, down-regulates profibrotic cytokines and decreases fibroblast proliferation. Pirfenidone leads to a reduction of TGF-beta2 mRNA levels and of the mature TGF-beta2 protein due to decreased expression and direct inhibition of the TGF-beta pro-protein convertase furin. In addition, pirfenidone reduces the protein levels of the matrix metalloproteinase (MMP)-11, a TGF-beta target gene and furin substrate involved in carcinogenesis.
Dosage forms of Pirfenidone
|Capsule, hard||Oral use||267 mg|
Hoffmann La Roche Limited
Humans and other mammals
Indication of Pirfenidone
For the treatment of idiopathic pulmonary fibrosis (IPF).
Toxicity of Pirfenidone
Generally well tolerated with the most frequent side effects reported being photosensitivity rash and gastrointestinal symptoms.
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