Save up -80% on Polymyxin B Sulfate

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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Polytrim

$101 eye dropper (10ml) 1mg/ml
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Polymyxin B Sulfate volume of distribution

No adverse events were reported during the study. Data on the renal function of the patients are presented in table 1. The plasma concentrations of polymyxin B over time for all patients are shown in figure 1. The peak plasma concentrations at the end of the 60-min infusion ranged from 2.38 to 13.9 mg/L. The concentrations of polymyxin B1 were ∼4-fold higher than the concentrations of polymyxin B2 (data not shown). The pharmacokinetic parameters of polymyxin B are summarized in table 2. There was relatively little interindividual variability in total body clearance (range, 0.27–0.81 mL/min/kg) and volume of distribution (range, 71–194 mL/kg).

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What is Polymyxin B Sulfate

Polymyxin B sulfate is a mixture of polymyxins B1 and B2, obtained from Bacillus polymyxa strains. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic. All gram-positive bacteria, fungi, and the gram-negative cocci, N. gonorrhea and N. menigitidis, are resistant. It is appropriate for treatment of infections of the urinary tract, meninges, and blood stream, caused by susceptible strains of Pseudomonas aeruginosa.

Polymyxin B Sulfate mechanism of action

Polymyxin B sulfate has a bactericidal action against almost all gram-negative bacilli except the Proteus group. Polymyxin B sulfate interacts with the lipopolysaccharide of the cytoplasmic outer membrane of Gram-negative bacteria, altering membrane permeability and causing cell death. It does not need to enter the cell.

Dosage forms of Polymyxin B Sulfate

Powder for solutionintramuscular; inhalation; intrathecal; intravenous; topical500000 unit
Ointment; padtopical

Prescription Generics


International Brands

10 Person Ansi


Polimixina B Polymyxin B


Genuine First Aid LLC

CAS number






Affected organisms

Enteric bacteria and other eubacteria

Indication of Polymyxin B Sulfate

For treatment of infections of the urinary tract, meninges, and blood stream, caused by susceptible strains of iPseudomonas aeruginosa/i.

Toxicity of Polymyxin B Sulfate

Overdose can cause stomach pains, vomiting, and diarrhea.

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