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2018 Price of Porfimer
Photofrin 75 mg vial
* price without discount in nearest pharmacy. Price may vary.
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What is Porfimer
The purified component of hematoporphyrin derivative, it consists of a mixture of oligomeric porphyrins. It is used in photodynamic therapy (hematoporphyrin photoradiation); to treat malignant lesions with visible light and experimentally as an antiviral agent. It is the first drug to be approved in the use of photodynamic therapy in the United States.
Porfimer mechanism of action
Cellular damage caused by porfimer is a consequence of the propagation of radical reactions. Radical initiation may occur after porfimer absorbs light to form a porphyrin excited state. Spin transfer from porfimer to molecular oxygen may then generate singlet oxygen. Subsequent radical reactions can form superoxide and hydroxyl radicals. Tumor death also occurs through ischemic necrosis secondary to vascular occlusion that appears to be partly mediated by thromboxane A2 release.
Dosage forms of Porfimer
|Injection, powder, for solution||intravenous||75 mg/31.8mL|
|Powder for solution||intravenous||15 mg|
|Powder for solution||intravenous||75 mg|
Dihaematoporphyrin Ether Dihematoporphyrin ether
Concordia Laboratories Inc
Humans and other mammals
Indication of Porfimer
Indicated in the treatment of esophageal cancer.
Toxicity of Porfimer
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