Save up -80% on Posaconazole
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2018 Price of Posaconazole
Noxafil 40 mg/ml suspension
* price without discount in nearest pharmacy. Price may vary.
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Posaconazole volume of distribution
* 1774 L
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
Posaconazole mechanism of action
As a triazole antifungal agent, posaconazole exerts its antifungal activity through blockage of the cytochrome P-450 dependent enzyme, sterol 14alpha;-demethylase, in fungi by binding to the heme cofactor located on the enzyme. This leads to the inhibition of the synthesis of ergosterol, a key component of the fungal cell membrane, and accumulation of methylated sterol precursors. This results in inhibition of fungal cell growth and ultimately, cell death.
Dosage forms of Posaconazole
|Noxafil||40mg/mL||105mL Oral Suspension||$1,055.00|
|Buscopan Ampules||20mg/mL||12 Ampules||$61.40|
Merck Sharp Dohme Corp.
Aspergillis, Candida and other fungi
Indication of Posaconazole
For prophylaxis of invasive emAspergillus /em and emCandida /em infections in patients, 13 years of age and older, who are at high risk of developing these infections due to being severely immunocompromised as a result of procedures such as hematopoietic stem cell transplant (HSCT) recipients with graft-versus-host disease (GVHD), or due to hematologic malignancies with prolonged neutropenia from chemotherapy. Also for the treatment of oropharyngeal candidiasis, including oropharyngeal candidiasis refractory to itraconazole and/or fluconazole. Posaconazole is used as an alternative treatment for invasive aspergillosis, emFusarium /em infections, and zygomycosis in patients who are intolerant of, or whose disease is refractory to, other antifungals.
Toxicity of Posaconazole
During the clinical trials, some patients received posaconazole up to 1600 mg/day with no adverse events noted that were different from the lower doses. In addition, accidental overdose was noted in one patient who took 1200 mg BID for 3 days. No related adverse events were noted by the investigator.
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