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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Posaconazole

Noxafil 40 mg/ml suspension

$7.08

ml

* price without discount in nearest pharmacy. Price may vary.

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Posaconazole volume of distribution

* 1774 L

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What is Posaconazole

Posaconazole is a triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients.

Posaconazole mechanism of action

As a triazole antifungal agent, posaconazole exerts its antifungal activity through blockage of the cytochrome P-450 dependent enzyme, sterol 14alpha;-demethylase, in fungi by binding to the heme cofactor located on the enzyme. This leads to the inhibition of the synthesis of ergosterol, a key component of the fungal cell membrane, and accumulation of methylated sterol precursors. This results in inhibition of fungal cell growth and ultimately, cell death.

Dosage forms of Posaconazole

DrugDosageQuantityPrice
Noxafil40mg/mL105mL Oral Suspension$1,055.00
Bisacodyl5mg100 Tablet$24.00
Buscopan10mg100 Tablet$53.50
Buscopan Ampules20mg/mL12 Ampules$61.40
Prescription Generics

false

International Brands

Noxafil

Synonyms

Manufacturers

Merck Sharp Dohme Corp.

CAS number

171228-49-2

UNII

6TK1G07BHZ

State

solid

Affected organisms

Aspergillis, Candida and other fungi

Indication of Posaconazole

For prophylaxis of invasive emAspergillus /em and emCandida /em infections in patients, 13 years of age and older, who are at high risk of developing these infections due to being severely immunocompromised as a result of procedures such as hematopoietic stem cell transplant (HSCT) recipients with graft-versus-host disease (GVHD), or due to hematologic malignancies with prolonged neutropenia from chemotherapy. Also for the treatment of oropharyngeal candidiasis, including oropharyngeal candidiasis refractory to itraconazole and/or fluconazole. Posaconazole is used as an alternative treatment for invasive aspergillosis, emFusarium /em infections, and zygomycosis in patients who are intolerant of, or whose disease is refractory to, other antifungals.

Toxicity of Posaconazole

During the clinical trials, some patients received posaconazole up to 1600 mg/day with no adverse events noted that were different from the lower doses. In addition, accidental overdose was noted in one patient who took 1200 mg BID for 3 days. No related adverse events were noted by the investigator.

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