Save up -80% on Pralidoxime

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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Pralidoxime

Protopam chloride 1 gm vial

$104.04

tablet

* price without discount in nearest pharmacy. Price may vary.

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What is Pralidoxime

Pralidoxime is an antidote to organophosphate pesticides and chemicals. Organophosphates bind to the esteratic site of acetylcholinesterase, which results initially in reversible inactivation of the enzyme. If given within 24 hours,after organophosphate exposure, pralidoxime reactivates the enzyme cholinesterase by cleaving the phosphate-ester bond formed between the organophosphate and acetylcholinesterase.

Pralidoxime mechanism of action

Pralidoxime is an antidote to organophosphate pesticides and chemicals. Organophosphates bind to the esteratic site of acetylcholinesterase, which results initially in reversible inactivation of the enzyme. Acetylcholinesterase inhibition causes acetylcholine to accumulate in synapses, producing continuous stimulation of cholinergic fibers throughout the nervous systems. If given within 24 hours after organophosphate exposure, pralidoxime reactivates the acetylcholinesterase by cleaving the phosphate-ester bond formed between the organophosphate and acetylcholinesterase.

Dosage forms of Pralidoxime

FormRouteStrength
Kitintramuscular
Injection, powder, lyophilized, for solutionintramuscular; intravenous; subcutaneous1 g/20mL
Powder for solutionintramuscular; intravenous; subcutaneous1 g
Prescription Generics

false

International Brands

Duodote

Synonyms

2-PAM Pralidoxim

Manufacturers

Meridian Medical Technologies , Inc.

CAS number

6735-59-7

UNII

P7MU9UTP52

State

solid

Affected organisms

Humans and other mammals

Indication of Pralidoxime

For the treatment of poisoning due to those pesticides and chemicals of the organophosphate class which have anticholinesterase activity and in the control of overdosage by anticholinesterase drugs used in the treatment of myasthenia gravis.

Toxicity of Pralidoxime

RX24 Drugs Disclaimer: before buying a Pralidoxime on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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