Save up -80% on Pralidoxime

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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Pralidoxime

Protopam chloride 1 gm vial

$104.04tablet
price without discount in nearest pharmacy. Price may vary.

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Pralidoxime volume of distribution

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2018 Statistics

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Discount Cards 16,000+

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Clients Benefit 29%

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Total savings $4,735,080

What is Pralidoxime

Pralidoxime is an antidote to organophosphate pesticides and chemicals. Organophosphates bind to the esteratic site of acetylcholinesterase, which results initially in reversible inactivation of the enzyme. If given within 24 hours,after organophosphate exposure, pralidoxime reactivates the enzyme cholinesterase by cleaving the phosphate-ester bond formed between the organophosphate and acetylcholinesterase.

Pralidoxime mechanism of action

Pralidoxime is an antidote to organophosphate pesticides and chemicals. Organophosphates bind to the esteratic site of acetylcholinesterase, which results initially in reversible inactivation of the enzyme. Acetylcholinesterase inhibition causes acetylcholine to accumulate in synapses, producing continuous stimulation of cholinergic fibers throughout the nervous systems. If given within 24 hours after organophosphate exposure, pralidoxime reactivates the acetylcholinesterase by cleaving the phosphate-ester bond formed between the organophosphate and acetylcholinesterase.

Dosage forms of Pralidoxime

FormRouteStrength
Kitintramuscular
Injection, powder, lyophilized, for solutionintramuscular; intravenous; subcutaneous1 g/20mL
Powder for solutionintramuscular; intravenous; subcutaneous1 g

Prescription Generics

false

International Brands

Duodote

Synonyms

2-PAM Pralidoxim

Manufacturers

Meridian Medical Technologies , Inc.

CAS number

6735-59-7

UNII

P7MU9UTP52

State

solid

Affected organisms

Humans and other mammals

Indication of Pralidoxime

For the treatment of poisoning due to those pesticides and chemicals of the organophosphate class which have anticholinesterase activity and in the control of overdosage by anticholinesterase drugs used in the treatment of myasthenia gravis.

Toxicity of Pralidoxime

RX24 Drugs Disclaimer: consult your healthcare provider before buying a Pralidoxime on prescription or using an RX manufacturer savings coupon. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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