Save up -80% on Pralidoxime
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2018 Price of Pralidoxime
Protopam chloride 1 gm vial
* price without discount in nearest pharmacy. Price may vary.
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Pralidoxime volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Pralidoxime
Pralidoxime is an antidote to organophosphate pesticides and chemicals. Organophosphates bind to the esteratic site of acetylcholinesterase, which results initially in reversible inactivation of the enzyme. If given within 24 hours,after organophosphate exposure, pralidoxime reactivates the enzyme cholinesterase by cleaving the phosphate-ester bond formed between the organophosphate and acetylcholinesterase.
Pralidoxime mechanism of action
Pralidoxime is an antidote to organophosphate pesticides and chemicals. Organophosphates bind to the esteratic site of acetylcholinesterase, which results initially in reversible inactivation of the enzyme. Acetylcholinesterase inhibition causes acetylcholine to accumulate in synapses, producing continuous stimulation of cholinergic fibers throughout the nervous systems. If given within 24 hours after organophosphate exposure, pralidoxime reactivates the acetylcholinesterase by cleaving the phosphate-ester bond formed between the organophosphate and acetylcholinesterase.
Dosage forms of Pralidoxime
|Injection, powder, lyophilized, for solution||intramuscular; intravenous; subcutaneous||1 g/20mL|
|Powder for solution||intramuscular; intravenous; subcutaneous||1 g|
Meridian Medical Technologies , Inc.
Humans and other mammals
Indication of Pralidoxime
For the treatment of poisoning due to those pesticides and chemicals of the organophosphate class which have anticholinesterase activity and in the control of overdosage by anticholinesterase drugs used in the treatment of myasthenia gravis.
Toxicity of Pralidoxime
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