Save up -80% on Pramlintide
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Symlinpen
|$939.83||1 carton (2 pens) 1.5ml|
|Price with discount in nearest pharmacy. Price may vary.|
We offer free Symlinpen coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Pramlintide every time. What are you waiting for? Claim your prescription drug card now!
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Pramlintide volume of distribution
The absolute bioavailability of a single subcutaneous dose of pramlintide is approximately 30 to 40%. Pramlintide does not extensively bind to blood cells or albumin (approximately 40% of the drug is unbound in plasma).
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Pramlintide
Pramlintide is a relatively new adjunct treatment for diabetes (both type 1 and 2), developed by Amylin Pharmaceuticals. It is derived from amylin, a hormone that is released into the bloodstream, in a similar pattern as insulin, after a meal. Like insulin, amylin is deficient in individuals with diabetes.
Pramlintide mechanism of action
Pramlintide is an amlyinomimetic, a functional analog of the naturally occurring pancreatic hormone amylin. Amylin has activity in a number of gastrointestinal and glucodynamic systems, and by mimicking its activity, pramlintide acts to improve glycemic control through modulation of the rate of gastric emptying, prevention of post-prandial rise in glucagon levels, and by increasing sensations of satiety, thereby reducing caloric intake and potentiating weight loss. There appears to be at least three distinct receptor complexes that bind with high affinity to amylin. All three complexes contain the calcitonin receptor at the core, plus one of three Receptor activity-modifying proteins, RAMP1, RAMP2, or RAMP3.
Dosage forms of Pramlintide
Astra Zeneca Pharmaceuticals Lp
Humans and other mammals
Indication of Pramlintide
For the treatment of type 1 and type 2 diabetes mellitus as an adjunct to preprandial insulin therapy in patients without adequate glycemic control of insulin therapy.
Toxicity of Pramlintide
In large clinical trials, serum enzyme elevations were rare (<1%) during pramlintide/insulin therapy and no more common than with placebo and there were no reports of clinically apparent liver injury among treated patients. Since licensure, there have been no published case reports of hepatotoxicity due to pramlintide and the product label does not list liver injury as an adverse event. Thus, liver injury due to pramlintide must be rare, if it occurs at all.
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