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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Pravastatin

Apo-Pravastatin 10 mg Tablet

$1.0

tablet

* price without discount in nearest pharmacy. Price may vary.

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Pravastatin volume of distribution

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What is Pravastatin

Pravastatin is a cholesterol-lowering agent that belongs to a class of medications known as statins. It was derived from microbial transformation of mevastatin, the first statin discovered. It is a ring-opened dihydroxyacid with a 6-hydroxyl group that does not require i in vivo /i activation. Pravastatin is one of the lower potency statins; however, its increased hydrophilicity is thought to confer advantages such as minimal penetration through lipophilic membranes of peripheral cells, increased selectivity for hepatic tissues, and a reduction in side effects compared with lovastatin and simvastatin.

Pravastatin mechanism of action

Pravastatin is structurally similar to the HMG, a substituent of the endogenous substrate of HMG-CoA reductase. Unlike its parent compound, mevastatin, and statins such as lovastatin and simvastatin, pravastatin does not need to be activated i in vivo /i . Its hydrolyzed lactone ring mimics the tetrahedral intermediate produced by the reductase allowing the agent to bind with a much greater affinity than its natural substrate. The bicyclic portion of pravastatin binds to the coenzyme A portion of the active site. Pravastatin sodium produces its lipid-lowering effect in two ways. First, as a consequence of its reversible inhibition of HMG-CoA reductase activity, it effects modest reductions in intracellular pools of cholesterol. This results in an increase in the number of LDL-receptors on cell surfaces and enhanced receptor-mediated catabolism and clearance of circulating LDL. Second, pravastatin inhibits LDL production by inhibiting hepatic synthesis of VLDL, the LDL precursor.

Dosage forms of Pravastatin

DrugDosageQuantityPrice
Pravachol10mg100 Tablet$180.00
Pravachol20mg100 Tablet$200.00
Pravachol40mg90 Tablet$228.00
Pravastatin20mg84 Tablet$59.00
Pravastatin40mg84 Tablet$81.00
Prescription Generics

false

International Brands

Ach-pravastatin

Synonyms

(+)-(3R,5R)-3,5-Dihydroxy-7-((1S,2S,6S,8S,8ar)-6-hydroxy-2-methyl-8-{((S)-2-methylbutyryl)oxy}-1,2,6,7,8,8a-hexahydro-1-naphthyl)heptanoic acid Pravastatin acid

Manufacturers

Accord Healthcare Inc

CAS number

81093-37-0

UNII

KXO2KT9N0G

State

solid

Affected organisms

Humans and other mammals

Indication of Pravastatin

For the treatment of hypercholesterolemia and to reduce the risk of cardiovascular disease.

Toxicity of Pravastatin

Side effects include diarrhea, nausea, constipation, gas abdominal pain, myopathy, myositis, rhabdomyolysis, and hepatotoxicity. LD sub 50 /sub = 12,000 mg/kg (orally in rat)

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