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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Biltricide

$170.426 tablets/600 mg
Price with discount in nearest pharmacy. Price may vary.

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Praziquantel volume of distribution

The terminal elimination half life of praziquantel is approximately 2 hours. The volume of distribution is around 8000 L and the clearance (CL/f) is 7.0 L/kg/hr. Praziquantel is between 80 and 85% bound to plasma proteins.

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What is Praziquantel

Praziquantel is a prescription drug used as anti-worm medication. It prevents newly hatched insect larvae (worms) from growing or multiplying in your body. Praziquantel is used to treat infections caused by Schistosoma worms, which enter the body through skin that has come into contact with contaminated water.

Praziquantel mechanism of action

Praziquantel works by causing severe spasms and paralysis of the worms’ muscles. This paralysis is accompanied – and probably caused – by a rapid Ca 2+ influx inside the schistosome. Morphological alterations are another early effect of praziquantel. These morphological alterations are accompanied by an increased exposure of schistosome antigens at the parasite surface. The worms are then either completely destroyed in the intestine or passed in the stool. An interesting quirk of praziquantel is that it is relatively ineffective against juvenile schistosomes. While initially effective, effectiveness against schistosomes decreases until it reaches a minimum at 3-4 weeks. Effectiveness then increases again until it is once again fully effective at 6-7 weeks. Glutathione S-transferase (GST), an essential detoxification enzyme in parasitic helminths, is a major vaccine target and a drug target against schistosomiasis. Schistosome calcium ion channels are currently the only known target of praziquantel.

Dosage forms of Praziquantel

FormRouteStrength
Tabletoral600 mg
Tablet, film coatedoral600 mg/1

Prescription Generics

false

International Brands

Biltricide

Synonyms

Biltricide

Manufacturers

Bayer Inc

CAS number

55268-74-1

UNII

6490C9U457

State

solid

Affected organisms

Indication of Praziquantel

Praziquantel is indicated for the treatment of infections due to: all species of schistosoma (for example, Schistosoma mekongi, Schistosoma japonicum, Schistosoma mansoni and Schistosoma hematobium), and infections due to the liver flukes

Toxicity of Praziquantel

The acute toxicity in rats, mice, rabbits and dogs is very low. Rats tolerated by oral administration doses of up to 1000 mg/kg repeated daily for four weeks, and dogs up to 180 mg/kg for 13 weeks without any organ damage. Praziquantel did not disturb reproduction in rats (up to F2-generation), nor did it reveal teratogenic effects in mice, rats and rabbits. In extensive mutagenicity trials performed by different laboratories worldwide, in a variety of test systems, no induction of point mutations, gene conversion, DNA-repair, sister chromatid exchanges (SCEs), or X-linked recessive lethals was detected. Besides, Salmonella tests with urines of praziquantel treated mice, rats, healthy and Schistosoma-infected persons gave no indication of a mutagenic effect. In different in vivo mammalian assays praziquantel not mutagenic either. Low toxicity of praziquantel was not mutagenic either. Low toxicity of praziquantel was demonstrated also in the combined chronic toxicity and carcinogenicity tests which were performed in rats and Syrian hamsters.

RX24 Drugs Disclaimer: consult your healthcare provider before buying a Praziquantel on prescription or using an RX manufacturer savings coupon. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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