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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Prednisolone

Millipred dp 5 mg dose pack tablet

$1.18

tablet

* price without discount in nearest pharmacy. Price may vary.

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Prednisolone volume of distribution

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What is Prednisolone

A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.

Prednisolone mechanism of action

Glucocorticoids such as Prednisolone can inhibit leukocyte infiltration at the site of inflammation, interfere with mediators of inflammatory response, and suppress humoral immune responses. The antiinflammatory actions of glucocorticoids are thought to involve phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes. Prednisolone reduces inflammatory reaction by limiting the capillary dilatation and permeability of the vascular structures. These compounds restrict the accumulation of polymorphonuclear leukocytes and macrophages and reduce the release of vasoactive kinins. Recent research suggests that corticosteroids may inhibit the release of arachidonic acid from phospholipids, thereby reducing the formation of prostaglandins. Prednisolone is a glucocorticoid receptor agonist. On binding, the corticoreceptor-ligand complex translocates itself into the cell nucleus, where it binds to many glucocorticoid response elements (GRE) in the promoter region of the target genes. The DNA bound receptor then interacts with basic transcription factors, causing an increase or decrease in expression of specific target genes, including suppression of IL2 (interleukin 2) expression.

Dosage forms of Prednisolone

DrugDosageQuantityPrice
Prednisolone1%5mL Eyedrops$40.00
Prednisolone1%10mL Eyedrops$67.00
Prednisolone1%15mL Eyedrops$94.00
Pred Mild Eyedrops0.12%10mL Eyedrops$48.00
Pred Forte1%10mL Suspension$35.00
Blephamide Eye Ointment0.2/10%3.5g Eye Ointment$46.00
Blephamide Eye Drops0.2/10%5mL Liquifilm Eye Drops$47.00
Blephamide Eye Drops0.2/10%10mL Liquifilm Eye Drops$78.00
Depo Medrol Injection20mg/mL5mL Vial$40.00
Methylprednisolone Acetate80mg/mL5x1mL Vial$72.00
Methylprednisolone Acetate40mg/mL10x1mL Vial$87.00
Medrol Acne Lotion2.5/100/50mg75mL Lotion$49.50
Medrol4mg40 Tablet$26.00
Medrol8mg84 Tablet$94.00
Medrol16mg100 Tablet$175.00
Prescription Generics

false

International Brands

Ak Tate Oph Sus 1%

Synonyms

(11beta)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione 1,4-Pregnadiene-11beta,17alpha,21-triol-3,20-dione

Manufacturers

Sandoz Canada Incorporated

CAS number

50-24-8

UNII

9PHQ9Y1OLM

State

solid

Affected organisms

Humans and other mammals

Indication of Prednisolone

For the treatment of primary or secondary adrenocortical insufficiency, such as congenital adrenal hyperplasia, thyroiditis. Also used to treat psoriatic arthritis, rheumatoid arthritis, ankylosing spondylitis, bursitis, acute gouty arthritis and epicondylitis. Also indicated for treatment of systemic lupus erythematosus, pemphigus and acute rhematic carditis. Can be used in the treatment of leukemias, lymphomas, thrombocytopenia purpura and autoimmune hemolytic anemia. Can be used to treat celiac disease, insulin resistance, ulcerative colitis and liver disorders.

Toxicity of Prednisolone

LDsub50/sub=500 mg/kg (oral, rat), short-term side effects include high blood glucose levels and fluid retention. Long term side effects include Cushing’s syndrome, weight gain, osteoporosis, glaucoma, type II diabetes and adrenal suppression.

RX24 Drugs Disclaimer: before buying a Prednisolone on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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