Save up -80% on Pregabalin
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2018 Price of Pregabalin
Lyrica 200 mg capsule
* price without discount in nearest pharmacy. Price may vary.
We offer free Pregabalin coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your discount card in most local pharmacies to get a discount on Pregabalin every time. What are you waiting for? Claim your prescription drug card now!
Pregabalin volume of distribution
Apparent volume of distribution, oral administration = 0.5 L/kg. Pregabalin has been shown to cross the placenta in rats and is present in the milk of lactating rats.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Pregabalin
Pregabalin is an anticonvulsant drug used for neuropathic pain, as an adjunct therapy for partial seizures, and in generalized anxiety disorder. It was designed as a more potent successor to gabapentin. Pregabalin is marketed by Pfizer under the trade name Lyrica. It is considered to have a dependence liability if misused, and is classified as a Schedule V drug in the U.S. (Wikipedia)
Pregabalin mechanism of action
Pregabalin binds with high affinity to the alpha2-delta site (an auxiliary subunit of voltage-gated calcium channels) in central nervous system tissues. Although the mechanism of action of pregabalin is unknown, results with genetically modified mice and with compounds structurally related to pregabalin (such as gabapentin) suggest that binding to the alpha2-delta subunit may be involved in pregabalin’s antinociceptive and antiseizure effects in animal models. In vitro, pregabalin reduces the calcium-dependent release of several neurotransmitters, possibly by modulation of calcium channel function. Studies also suggest that the descending noradrenergic and serotonergic pathways originating from the brainstem may be involved with the mechanism of pregabalin. Interestingly, although pregabalin is a structural derivative of inhibitory neurotransmitter gamma-aminobutyric acid (GABA), it does not bind directly to GABA or benzodiazepine receptors. The sodium channels, opiate receptors, and cyclooxygenase enzymes are not involved with the mechanism of pregabalin. It is also inactive at serotonin and dopamine receptors and does not inhibit dopamine, serotonin, or noradrenaline reuptake.
Dosage forms of Pregabalin
(S)-3-Isobutyl gaba 3-Isobutyl gaba
Accord Healthcare Inc
Humans and other mammals
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