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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Probenecid

Probenecid 500 mg tablet

$1.37

tablet

* price without discount in nearest pharmacy. Price may vary.

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Probenecid volume of distribution

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What is Probenecid

The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.

Probenecid mechanism of action

Probenecid inhibits the tubular reabsorption of urate, thus increasing the urinary excretion of uric acid and decreasing serum urate levels. Probenecid may also reduce plasma binding of urate and inhibit renal secretion of uric acid at subtherapeutic concentrations. The mechanism by which probenecid inhibits renal tubular transport is not known, but the drug may inhibit transport enzymes that require a source of high energy phosphate bonds and/or nonspecifically interfere with substrate access to protein receptor sites on the kidney tubules.

Dosage forms of Probenecid

FormRouteStrength
Tabletoral500 mg
Capsule; tabletoral
Tabletoral500 mg/1
Prescription Generics

false

International Brands

Benemid Tab 500mg

Synonyms

4-((Dipropylamino)sulfonyl)benzoic acid 4-(Di-N-propylsulfamoyl)benzoesaeure

Manufacturers

Merck Frosst Canada Cie, Merck Frosst Canada Co.

CAS number

57-66-9

UNII

PO572Z7917

State

solid

Affected organisms

Humans and other mammals

Indication of Probenecid

For the reduction of serum uric acid concentrations in chronic gouty arthritis and tophaceous gout in patients with frequent disabling gout attacks. Has also been effectively used to promote uric acid excretion in hyperuricemia secondary to the administration of thiazide and related diuretics.

Toxicity of Probenecid

RX24 Drugs Disclaimer: before buying a Probenecid on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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