Save up -80% on Probenecid
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Benemid
|$22.37||60 tablets/500 mg|
|Price with discount in nearest pharmacy. Price may vary.|
We offer free Probenecid coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Probenecid every time. What are you waiting for? Claim your prescription drug card now!
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Probenecid volume of distribution
At a plasma concentration of 14 ug/ml, about 75% of the drug is bound to proteins. Probenecid concentrations in the CSF are approximately 2% of plasma concentrations. The drug also crosses the placenta.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Probenecid
The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
Probenecid mechanism of action
Probenecid inhibits the tubular reabsorption of urate, thus increasing the urinary excretion of uric acid and decreasing serum urate levels. Probenecid may also reduce plasma binding of urate and inhibit renal secretion of uric acid at subtherapeutic concentrations. The mechanism by which probenecid inhibits renal tubular transport is not known, but the drug may inhibit transport enzymes that require a source of high energy phosphate bonds and/or nonspecifically interfere with substrate access to protein receptor sites on the kidney tubules.
Dosage forms of Probenecid
Benemid Tab 500mg
4-((Dipropylamino)sulfonyl)benzoic acid 4-(Di-N-propylsulfamoyl)benzoesaeure
Merck Frosst Canada Cie, Merck Frosst Canada Co.
Humans and other mammals
Indication of Probenecid
For the reduction of serum uric acid concentrations in chronic gouty arthritis and tophaceous gout in patients with frequent disabling gout attacks. Has also been effectively used to promote uric acid excretion in hyperuricemia secondary to the administration of thiazide and related diuretics.
Toxicity of Probenecid
There are no reports on the frequency of liver test abnormalities during probenecid therapy, but they are probably rare as the drug is largely secreted unchanged in the urine. A single case report of a severe hypersensitivity reaction from probenecid and rechallenge with severe recurrence of jaundice was reported over 50 years ago.
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