Save up -80% on Procarbazine
Note: this is a drug discount program, not an insurance plan.
2018 Price of Procarbazine
Matulane 50 mg capsule
* price without discount in nearest pharmacy. Price may vary.
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Procarbazine volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
Procarbazine mechanism of action
The precise mode of cytotoxic action of procarbazine has not been clearly defined. There is evidence that the drug may act by inhibition of protein, RNA and DNA synthesis. Studies have suggested that procarbazine may inhibit transmethylation of methyl groups of methionine into t-RNA. The absence of functional t-RNA could cause the cessation of protein synthesis and consequently DNA and RNA synthesis. In addition, procarbazine may directly damage DNA. Hydrogen peroxide, formed during the auto-oxidation of the drug, may attack protein sulfhydryl groups contained in residual protein which is tightly bound to DNA.
Dosage forms of Procarbazine
Sigma Tau Pharmaceuticals Inc
Humans and other mammals
Indication of Procarbazine
For use with other anticancer drugs for the treatment of stage III and stage IV Hodgkin’s disease.
Toxicity of Procarbazine
LD sub50 /sub=785 mg/kg (orally in rats)
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