Save up -80% on Procarbazine

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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Procarbazine

Matulane 50 mg capsule

$55.68

capsule

* price without discount in nearest pharmacy. Price may vary.

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Procarbazine volume of distribution

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What is Procarbazine

An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin’s disease.

Procarbazine mechanism of action

The precise mode of cytotoxic action of procarbazine has not been clearly defined. There is evidence that the drug may act by inhibition of protein, RNA and DNA synthesis. Studies have suggested that procarbazine may inhibit transmethylation of methyl groups of methionine into t-RNA. The absence of functional t-RNA could cause the cessation of protein synthesis and consequently DNA and RNA synthesis. In addition, procarbazine may directly damage DNA. Hydrogen peroxide, formed during the auto-oxidation of the drug, may attack protein sulfhydryl groups contained in residual protein which is tightly bound to DNA.

Dosage forms of Procarbazine

DrugDosageQuantityPrice
Procarbazine50mg50 Capsule$134.00
Prescription Generics

false

International Brands

Matulane

Synonyms

1-Methyl-2-(P-(isopropylcarbamoyl)benzyl)hydrazine 2-(P-Isopropylcarbamoylbenzyl)-1-methylhydrazine

Manufacturers

Sigma Tau Pharmaceuticals Inc

CAS number

671-16-9

UNII

35S93Y190K

State

solid

Affected organisms

Humans and other mammals

Indication of Procarbazine

For use with other anticancer drugs for the treatment of stage III and stage IV Hodgkin’s disease.

Toxicity of Procarbazine

LD sub50 /sub=785 mg/kg (orally in rats)

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