Save up -80% on Prochlorperazine
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Compazine
|$8.22||30 tablets/10 mg|
|price without discount in nearest pharmacy. Price may vary.|
We offer free Prochlorperazine coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Prochlorperazine every time. What are you waiting for? Claim your prescription drug card now!
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Prochlorperazine volume of distribution
The volume of distribution was large (12.9 1 kg-1) after i.v. dosing.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Prochlorperazine
A phenothiazine antipsychotic used principally in the treatment of nausea; vomiting; and vertigo. It is more likely than chlorpromazine to cause extrapyramidal disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p612)
Prochlorperazine mechanism of action
The mechanism of action of prochlorperazine has not been fully determined, but may be primarily related to its antidopaminergic effects. Prochlorperazine blocks the D2 somatodendritic autoreceptor, resulting in the blockade of postsynaptic dopamine receptors in the mesolimbic system and an increased dopamine turnover. Prochlorperazine also has anti-emetic effects, which can be attributed to dopamine blockade in the chemoreceptor trigger zone. Prochlorperazine also blocks anticholinergic and alpha-adrenergic receptors, the blockade of alpha(1)-adrenergic receptors resulting in sedation, muscle relaxation, and hypotension.
Dosage forms of Prochlorperazine
|Solution||intramuscular; intravenous||5 mg|
PBM Pharmaceuticals, Inc.
Humans and other mammals
Indication of Prochlorperazine
For the symptomatic management of psychotic disorders, short term management of nonpsychotic anxiety in patients with generalized anxiety disorder, and for the control of severe nausea and vomiting of various causes.
Toxicity of Prochlorperazine
Symptoms of central nervous system depression to the point of somnolence or coma. Agitation and restlessness may also occur. Other possible manifestations include convulsions, EKG changes and cardiac arrhythmias, fever and autonomic reactions such as hypotension, dry mouth and ileus; LD sub50 /sub=400mg/kg (orally in mice)
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