Save up -80% on Progesterone

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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Prometrium

$21.6930 capsules/100 mg
Price with discount in nearest pharmacy. Price may vary.

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Progesterone volume of distribution

The distribution and elimination phase half-lives were 0.13 +/- 0.024 (mean +/- SD) and 1.21 +/- 0.21 h, respectively. Elimination of the steroid was rapid with a total clearance of 2.75 +/- 0.42 l h-1 kg-1. Progesterone was widely distributed in the rat with a steady state volume of distribution of 2.36 +/- 0.23 l kg-1, a volume of the central compartment of 0.86 +/- 0.24 l kg-1 and a volume of the peripheral compartment of 1.50 +/- 0.19 l kg-1. The results of this study suggest that the ovariectomized female rat is a suitable animal model for examining the pharmacokinetics of progesterone.

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What is Progesterone

The major progestational steroid that is secreted primarily by the corpus luteum and the placenta. Progesterone acts on the uterus, the mammary glands, and the brain. It is required in embryo implantation, pregnancy maintenance, and the development of mammary tissue for milk production. Progesterone, converted from pregnenolone, also serves as an intermediate in the biosynthesis of gonadal steroid hormones and adrenal corticosteroids.

Progesterone mechanism of action

Progesterone shares the pharmacological actions of the progestins. Progesterone binds to the progesterone and estrogen receptors. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Once bound to the receptor, progestins like Progesterone will slow the frequency of release of gonadotropin releasing hormone (GnRH) from the hypothalamus and blunt the pre-ovulatory LH (luteinizing hormone) surge. In women who have adequate endogenous estrogen, progesterone transforms a proliferative endometrium into a secretory one. Progesterone is essential for the development of decidual tissue and is necessary to increase endometrial receptivity for implantation of an embryo. Once an embryo has been implanted, progesterone acts to maintain the pregnancy. Progesterone also stimulates the growth of mammary alveolar tissue and relaxes uterine smooth muscle. It has little estrogenic and androgenic activity.

Dosage forms of Progesterone

Progesterone100mg100 Soft Gel Capsules$85.00
Progesterone200mg100 Soft Gel Capsule$115.00
Progesterone400mg90 Soft Gel Capsule$205.00
Progesterone400mg90 Soft Gel Capsule$205.00
Prometrium100mg90 Soft Capsule$111.00
Progesterone Injection50mg/1mL10mL Solution for Injection$99.00
Medroxyprogesterone2.5mg100 Tablet$35.00
Medroxyprogesterone5mg100 Tablet$39.00
Medroxyprogesterone10mg100 Tablet$47.20
Depo Provera Injection150mg/mL1mL Vial$57.00
Prempro Low Dose1.5/0.3mg84days Tablet$590.00
Provera2.5mg100 Tablet$55.00
Provera5mg100 Tablet$69.00

Prescription Generics


International Brands

Act Progesterone Injection


(S)-4-Pregnene-3,20-dione (S)-Pregn-4-en-3,20-dione


Actavis Pharma Company

CAS number






Affected organisms

Humans and other mammals

Indication of Progesterone

For progesterone supplementation or replacement as part of an Assisted Reproductive Technology (ART) treatment for infertile women with progesterone deficiency and for the treatment of secondary amenorrhea. Also used for the reduction of the incidence of endometrial hyperplasia and the attendant risk of endometrial carcinoma in postmenopausal women receiving estrogen replacement therapy, as well as treatment of abnormal uterine bleeding due to hormonal imbalance in the absence of organic pathology such as fibroids or uterine cancer.

Toxicity of Progesterone

Progesterone should be used with caution, and only with careful monitoring, in patients with conditions that might be aggravated by fluid retention (eg, asthma, seizure disorders, migraine, or cardiac or renal dysfunction). The drug should also be used with caution in patients with a history of mental depression; progesterone should be discontinued if depression recurs to a serious degree during therapy with the drug.

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