Save up -80% on Promazine

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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

Pharmacists and Patients support.

2018 Price of Promazine

Chlorpromazine 200 mg tablet

$1.05

tablet

* price without discount in nearest pharmacy. Price may vary.

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Promazine volume of distribution

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What is Promazine

A phenothiazine with actions similar to chlorpromazine but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic. Promazine is not approved for use in the United States.

Promazine mechanism of action

Promazine is an antagonist at types 1, 2, and 4 dopamine receptors, 5-HT receptor types 2A and 2C, muscarinic receptors 1 through 5, alpha(1)-receptors, and histamine H1-receptors. Promazine’s antipsychotic effect is due to antagonism at dopamine and serotonin type 2 receptors, with greater activity at serotonin 5-HT2 receptors than at dopamine type-2 receptors. This may explain the lack of extrapyramidal effects. Promazine does not appear to block dopamine within the tubero-infundibular tract, explaining the lower incidence of hyperprolactinemia than with typical antipsychotic agents or risperidone. Antagonism at muscarinic receptors, H1-receptors, and alpha(1)-receptors also occurs with promazine.

Dosage forms of Promazine

FormRouteStrength
Liquidintramuscular; intravenous50 mg
Prescription Generics

false

International Brands

Promazine HCl Inj 50mg/ml

Synonyms

10-(3-(Dimethylamino)propyl)phenothiazine Frenil

Manufacturers

Abbott Laboratories, Limited

CAS number

58-40-2

UNII

O9M39HTM5W

State

liquid

Affected organisms

Humans and other mammals

Indication of Promazine

Used as an adjunct for short term treatment of moderate and severe psychomotor agitation. Also used to treat agitation or restlessness in the elderly.

Toxicity of Promazine

Side effects include: extrapyramidal symptoms, drowsiness, weight gain, dry mouth, constipation, endocrine effects (such as gynaecomastia and menstrual disturbance), sensitivity to sunlight and haemolytic anaemia.

RX24 Drugs Disclaimer: before buying a Promazine on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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