Save up -80% on Propylthiouracil

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RX BIN: 015558
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Propylthiouracil

Propylthiouracil 50 mg tablet



* price without discount in nearest pharmacy. Price may vary.

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Propylthiouracil volume of distribution

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What is Propylthiouracil

A thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of throxine to tri-iodothyronine. It is used in the treatment of hyperthyroidism. (From Martindale, The Extra Pharmacopeoia, 30th ed, p534)

Propylthiouracil mechanism of action

Propylthiouracil binds to thyroid peroxidase and thereby inhibits the conversion of iodide to iodine. Thyroid peroxidase normally converts iodide to iodine (via hydrogen peroxide as a cofactor) and also catalyzes the incorporation of the resulting iodide molecule onto both the 3 and/or 5 positions of the phenol rings of tyrosines found in thyroglobulin. Thyroglobulin is degraded to produce thyroxine (T4) and tri-iodothyronine (T3), which are the main hormones produced by the thyroid gland. Therefore propylthiouracil effectively inhibits the production of new thyroid hormones.

Dosage forms of Propylthiouracil

Tabletoral100 mg
Tabletoral50 mg
Tabletoral50 mg/1
Prescription Generics


International Brands



2-Mercapto-6-propyl-4-pyrimidone 2-Mercapto-6-propylpyrimid-4-one


Apotex Inc

CAS number






Affected organisms

Humans and other mammals

Indication of Propylthiouracil

Used to manage hyperthyroidism which is due to an overactive thyroid gland (Grave’s disease).

Toxicity of Propylthiouracil

Oral, rat: LD sub50 /sub = 1250 mg/kg.

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