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Price of Propylthiouracil
Propylthiouracil 50 mg tablet
* price without discount in nearest pharmacy. Price may vary.
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Propylthiouracil volume of distribution
What is Propylthiouracil
A thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of throxine to tri-iodothyronine. It is used in the treatment of hyperthyroidism. (From Martindale, The Extra Pharmacopeoia, 30th ed, p534)
Propylthiouracil mechanism of action
Propylthiouracil binds to thyroid peroxidase and thereby inhibits the conversion of iodide to iodine. Thyroid peroxidase normally converts iodide to iodine (via hydrogen peroxide as a cofactor) and also catalyzes the incorporation of the resulting iodide molecule onto both the 3 and/or 5 positions of the phenol rings of tyrosines found in thyroglobulin. Thyroglobulin is degraded to produce thyroxine (T4) and tri-iodothyronine (T3), which are the main hormones produced by the thyroid gland. Therefore propylthiouracil effectively inhibits the production of new thyroid hormones.
Dosage forms of Propylthiouracil
Humans and other mammals
Indication of Propylthiouracil
Used to manage hyperthyroidism which is due to an overactive thyroid gland (Grave’s disease).
Toxicity of Propylthiouracil
Oral, rat: LD sub50 /sub = 1250 mg/kg.
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