Save up -80% on Propylthiouracil
Note: this is a drug discount program, not an insurance plan.
2018 Price of Propylthiouracil
Propylthiouracil 50 mg tablet
* price without discount in nearest pharmacy. Price may vary.
We offer free Propylthiouracil coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your discount card in most local pharmacies to get a discount on Propylthiouracil every time. What are you waiting for? Claim your prescription drug card now!
Propylthiouracil volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Propylthiouracil
A thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of throxine to tri-iodothyronine. It is used in the treatment of hyperthyroidism. (From Martindale, The Extra Pharmacopeoia, 30th ed, p534)
Propylthiouracil mechanism of action
Propylthiouracil binds to thyroid peroxidase and thereby inhibits the conversion of iodide to iodine. Thyroid peroxidase normally converts iodide to iodine (via hydrogen peroxide as a cofactor) and also catalyzes the incorporation of the resulting iodide molecule onto both the 3 and/or 5 positions of the phenol rings of tyrosines found in thyroglobulin. Thyroglobulin is degraded to produce thyroxine (T4) and tri-iodothyronine (T3), which are the main hormones produced by the thyroid gland. Therefore propylthiouracil effectively inhibits the production of new thyroid hormones.
Dosage forms of Propylthiouracil
Humans and other mammals
Indication of Propylthiouracil
Used to manage hyperthyroidism which is due to an overactive thyroid gland (Grave’s disease).
Toxicity of Propylthiouracil
Oral, rat: LD sub50 /sub = 1250 mg/kg.
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