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RX BIN: 015558
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Protriptyline

Norpramin 10 mg tablet



* price without discount in nearest pharmacy. Price may vary.

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What is Protriptyline

Protriptyline hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, protriptyline does not affect mood or arousal, but may cause sedation. In depressed individuals, protriptyline exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. In addition, TCAs down-regulate cerebral cortical beta;-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block histamine H sub 1 /sub receptors, alpha; sub 1 /sub -adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively. See toxicity section below for a complete listing of side effects. Protriptyline may be used for the treatment of depression.

Protriptyline mechanism of action

Protriptyline acts by decreasing the reuptake of norepinephrine and serotonin (5-HT).

Dosage forms of Protriptyline

Tabletoral10 mg/1
Tabletoral5 mg/1
Tablet, film coatedoral10 mg/1
Prescription Generics


International Brands

Protriptyline Hydrochloride


3-(5H-dibenzo(a,d)(7)annulen-5-yl)-N-methylpropan-1-amine 3-(5H-Dibenzo(a,D)cyclohepten-5-yl)-N-methyl-1-propanamine


Epic Pharma, LLC

CAS number






Affected organisms

Humans and other mammals

Indication of Protriptyline

For the treatment of depression.

Toxicity of Protriptyline

Side effects include anxiety, blood disorders, confusion, decreased libido, dizziness, flushing, headache, impotence, insomnia, low blood pressure, nightmares, rapid or irregular heartbeat, rash, seizures, sensitivity to sunlight, stomach and intestinal discomfort, sedation, hypotension, blurred vision, dry mouth, constipation, urinary retention, postural hypotension, tachycardia, hypertension, ECG changes, heart failure, impaired memory and delirium, and precipitation of hypomanic or manic episodes in bipolar depression. Withdrawal symptoms include gastrointestinal disturbances, anxiety, and insomnia.

RX24 Drugs Disclaimer: before buying a Protriptyline on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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