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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Vivactil

$38.4030 tablets/10mg
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We offer free Vivactil coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Protriptyline every time. What are you waiting for? Claim your prescription drug card now!

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Protriptyline volume of distribution

Single dose studies in 5 volunteers suggest that the volume of distribution of protriptyline shows little intersubject variation. The half life of the drug, however, may vary appreciably from subject to subject, ranging from 54 to 198 h. The effects of two sedatives on mean protriptyline plasma levels have been determined. Mean plasma levels for nitrazepam recipients are indistinguishable from those for patients receiving no night sedation. The mean plasma levels for a group of patients receiving sodium amylobarbitone were significantly reduced.

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Clients Benefit 29%

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Total savings $4,735,080

What is Protriptyline

Protriptyline hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, protriptyline does not affect mood or arousal, but may cause sedation. In depressed individuals, protriptyline exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. In addition, TCAs down-regulate cerebral cortical beta;-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block histamine H sub 1 /sub receptors, alpha; sub 1 /sub -adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively. See toxicity section below for a complete listing of side effects. Protriptyline may be used for the treatment of depression.

Protriptyline mechanism of action

Protriptyline acts by decreasing the reuptake of norepinephrine and serotonin (5-HT).

Dosage forms of Protriptyline

FormRouteStrength
Tabletoral10 mg/1
Tabletoral5 mg/1
Tablet, film coatedoral10 mg/1

Prescription Generics

true

International Brands

Protriptyline Hydrochloride

Synonyms

3-(5H-dibenzo(a,d)(7)annulen-5-yl)-N-methylpropan-1-amine 3-(5H-Dibenzo(a,D)cyclohepten-5-yl)-N-methyl-1-propanamine

Manufacturers

Epic Pharma, LLC

CAS number

438-60-8

UNII

4NDU154T12

State

solid

Affected organisms

Humans and other mammals

Indication of Protriptyline

For the treatment of depression.

Toxicity of Protriptyline

Side effects include anxiety, blood disorders, confusion, decreased libido, dizziness, flushing, headache, impotence, insomnia, low blood pressure, nightmares, rapid or irregular heartbeat, rash, seizures, sensitivity to sunlight, stomach and intestinal discomfort, sedation, hypotension, blurred vision, dry mouth, constipation, urinary retention, postural hypotension, tachycardia, hypertension, ECG changes, heart failure, impaired memory and delirium, and precipitation of hypomanic or manic episodes in bipolar depression. Withdrawal symptoms include gastrointestinal disturbances, anxiety, and insomnia.

RX24 Drugs Disclaimer: consult your healthcare provider before buying a Protriptyline on prescription or using an RX manufacturer savings coupon. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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