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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Diclegis

$128.6760 tablets/10 mg
price without discount in nearest pharmacy. Price may vary.

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Pyridoxine volume of distribution

Stored mainly in liver. Total body store about 167 mg. Pyridoxal and pyridoxal phosphate most common forms found in blood; highly protein-bound. Pyridoxal crosses the placental barrier; fetal plasma levels five times greater than maternal plasma levels. After maternal intake of 2.5 to 5 mg daily of pyridoxine, level of vitamin in breast milk is about 240 ng/ml.

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What is Pyridoxine

Pyridoxine is the 4-methanol form of vitamin B6 and is converted to pyridoxal 5-phosphate in the body. Pyridoxal 5-phosphate is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. Although pyridoxine and vitamin B6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading.

Pyridoxine mechanism of action

Vitamin B6 is the collective term for a group of three related compounds, pyridoxine (PN), pyridoxal (PL) and pyridoxamine (PM), and their phosphorylated derivatives, pyridoxine 5′-phosphate (PNP), pyridoxal 5′-phosphate (PLP) and pyridoxamine 5′-phosphate (PMP). Although all six of these compounds should technically be referred to as vitamin B6, the term vitamin B6 is commonly used interchangeably with just one of them, pyridoxine. Vitamin B6, principally in its biologically active coenzyme form pyridoxal 5′-phosphate, is involved in a wide range of biochemical reactions, including the metabolism of amino acids and glycogen, the synthesis of nucleic acids, hemogloblin, sphingomyelin and other sphingolipids, and the synthesis of the neurotransmitters serotonin, dopamine, norepinephrine and gamma-aminobutyric acid (GABA).

Dosage forms of Pyridoxine

Liquid; capsuleoral
Tablet (extended-release)oral500 mg

Prescription Generics


International Brands

A.R.T.H. Away Formula


2-Methyl-3-hydroxy-4,5-dihydroxymethylpyridine 3-hydroxy-4,5-bis(hydroxymethyl)-2-methylpyridine


Abundance Marketing Ltd.

CAS number






Affected organisms

Humans and other mammals

Indication of Pyridoxine

For the treatment of vitamin B6 deficiency and for the prophylaxis of isoniazid-induced peripheral neuropathy.

Toxicity of Pyridoxine

Oral Rat LD50 = 4 gm/kg. Toxic effects include convulsions, dyspnea, hypermotility, diarrhea, ataxia and muscle weakness.

RX24 Drugs Disclaimer: consult your healthcare provider before buying a Pyridoxine on prescription or using an RX manufacturer savings coupon. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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What is Diclegis?

Diclegis is a sustained release tablet containing a combination of doxylamine and pyridoxine. Doxylamine is an antihistamine that reduces the effects of natural chemical histamine in the body. Pyridoxine is a form of vitamin B6. Diclegis is used to treat nausea and vomiting during pregnancy, sometimes called morning nausea.

Do not use Diclegis if you have used a MAO inhibitor in the last 14 days. Dangerous drug interactions can occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, fenelzine, rasagiline, selegiline, tranylcypromine, and others.