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Price of Pyrimethamine
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Pyrimethamine volume of distribution
What is Pyrimethamine
One of the folic acid antagonists that is used as an antimalarial or with a sulfonamide to treat toxoplasmosis. (PubChem)
Pyrimethamine mechanism of action
Pyrimethamine inhibits the dihydrofolate reductase of plasmodia and thereby blocks the biosynthesis of purines and pyrimidines, which are essential for DNA synthesis and cell multiplication. This leads to failure of nuclear division at the time of schizont formation in erythrocytes and liver.
Dosage forms of Pyrimethamine
Amedra Pharmaceuticals LLC
Indication of Pyrimethamine
For the treatment of toxoplasmosis and acute malaria; For the prevention of malaria in areas non-resistant to pyrimethamine
Toxicity of Pyrimethamine
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