Save up -80% on Quinidine

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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Quinora

$17.5890 tablets/200 mg
Price with discount in nearest pharmacy. Price may vary.

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Quinidine volume of distribution

Many of the metabolites appear to be pharmacologically active. Typical ranges for kinetic properties of quinidine in healthy persons are: apparent volume of distribution 2.0 to 3.5 litres/kg: elimination half-life 5 to 12 hours; clearance, 2.5 to 5.0ml/min/kg.

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2018 Statistics

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Discount Cards 16,000+

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Clients Benefit 29%

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Total savings $4,735,080

What is Quinidine

An optical isomer of quinine, extracted from the bark of the Cinchona tree and similar plant species. This alkaloid dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. It prolongs cellular action potential, and decreases automaticity. Quinidine also blocks muscarinic and alpha-adrenergic neurotransmission.

Quinidine mechanism of action

Quinidine acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation. The antiarrhythmic actions are mediated through effects on sodium channels in Purkinje fibers. Quinidine may also act on the slow inward calcium current (ICa), the rapid (IKr) and slow (IKs) components of the delayed potassium rectifier current, the inward potassium rectifier current (IKI), the ATP-sensitive potassium channel (IKATP) and Ito.

Dosage forms of Quinidine

FormRouteStrength
Tabletoral275 mg
Capsule, gelatin coatedoral
Tabletoral325 mg

Prescription Generics

true

International Brands

Apo Quinidine Tab 200mg

Synonyms

(+)-quinidine (8R,9S)-Quinidine

Manufacturers

Apotex Inc

CAS number

56-54-2

UNII

ITX08688JL

State

solid

Affected organisms

Humans and other mammals

Indication of Quinidine

For the treatment of ventricular pre-excitation and cardiac dysrhythmias

Toxicity of Quinidine

Toxic effects appear within 2 – 4 hours after ingestion but the delay may vary according to the quinidine salt and to the preparation forms. Symptoms may include disturbances of cardiac rhythm (especially in patients with underlying cardiovascular disease), neurotoxicity and respiratory depression. Diagnosis: Cardiac disturbances: circulatory arrest, shock, conduction disturbances, ventricular arrhythmias, ECG changes, Neurological symptoms: tinnitus, drowsiness, syncope, coma, convulsions, delirium.

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