Save up -80% on Rabeprazole
Note: this is a drug discount program, not an insurance plan.
2018 Price of Rabeprazole
Pariet 20 mg Enteric-Coated Tablet
* price without discount in nearest pharmacy. Price may vary.
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Rabeprazole volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Rabeprazole
Rabeprazole is an antiulcer drug in the class of proton pump inhibitors. It is a prodrug – in the acid environment of the parietal cells it turns into active sulphenamide form. Rabeprazole inhibits the H+, K+ATPase of the coating gastric cells and dose-dependent oppresses basal and stimulated gastric acid secretion.
Rabeprazole mechanism of action
Rabeprazole belongs to a class of antisecretory compounds (substituted benzimidazole proton-pump inhibitors) that do not exhibit anticholinergic or histamine H2-receptor antagonist properties, but suppress gastric acid secretion by inhibiting the gastric H sup+ /sup/K sup+ /supATPase (hydrogen-potassium adenosine triphosphatase) at the secretory surface of the gastric parietal cell. Because this enzyme is regarded as the acid (proton) pump within the parietal cell, rabeprazole has been characterized as a gastric proton-pump inhibitor. Rabeprazole blocks the final step of gastric acid secretion. In gastric parietal cells, rabeprazole is protonated, accumulates, and is transformed to an active sulfenamide. When studied in vitro, rabeprazole is chemically activated at pH 1.2 with a half-life of 78 seconds.
Dosage forms of Rabeprazole
|Tablet, coated||oral||20 mg/1|
|Capsule, delayed release||oral||10 mg/1|
|Capsule, delayed release||oral||5 mg/1|
Bgp Pharma Ulc
Humans and other mammals
Toxicity of Rabeprazole
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