Save up -80% on Raloxifene

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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Evista

$26.3430 tablets/60mg
Price with discount in nearest pharmacy. Price may vary.

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We offer free Evista coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Raloxifene every time. What are you waiting for? Claim your prescription drug card now!

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Raloxifene volume of distribution

After oral administration, about 60% of raloxifene is absorbed. Absolute bioavailability is 2%. Distribution: Apparent volume of distribution is 2,348 L/kg, independent of dose administered.

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2018 Statistics

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Discount Cards 16,000+

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Clients Benefit 29%

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Total savings $4,735,080

What is Raloxifene

A second generation selective estrogen receptor modulator (SERM) used to prevent osteoporosis in postmenopausal women. It has estrogen agonist effects on bone and cholesterol metabolism but behaves as a complete estrogen antagonist on mammary gland and uterine tissue.

Raloxifene mechanism of action

Raloxifene binds to estrogen receptors, resulting in differential expression of multiple estrogen-regulated genes in different tissues. Raloxifene produces estrogen-like effects on bone, reducing resorption of bone and increasing bone mineral density in postmenopausal women, thus slowing the rate of bone loss. The maintenance of bone mass by raloxifene and estrogens is, in part, through the regulation of the gene-encoding transforming growth factor-.3 (TGF-.3), which is a bone matrix protein with antiosteoclastic properties. Raloxifene activates TGF-.3 through pathways that are estrogen receptor-mediated but involve DNA sequences distinct from the estrogen response element. The drug also binds to the estrogen receptor and acts as an estrogen agonist in preosteoclastic cells, which results in the inhibtion of their proliferative capacity. This inhibition is thought to contribute to the drug’s effect on bone resorption. Other mechanisms include the suppression of activity of the bone-resorbing cytokine interleukin-6 promoter activity. Raloxifene also antagonizes the effects of estrogen on mammary tissue and blocks uterotrophic responses to estrogen. By competing with estrogens for the estrogen receptors in reproductive tissue, raloxifene prevents the transcriptional activation of genes containing the estrogen response element. As well, raloxifene inhibits the estradiol-dependent proliferation of MCF-7 human mammary tumor cells in vitro. The mechansim of action of raloxifene has not been fully determined, but evidence suggests that the drug’s tissue-specific estrogen agonist or antagonist activity is related to the structural differences between the raloxifene-estrogen receptor complex (specifically the surface topography of AF-2) and the estrogen-estrogen receptor complex. Also, the existence of at least 2 estrogen receptors (ER., ER.) may contribute to the tissue specificity of raloxifene.

Dosage forms of Raloxifene

DrugDosageQuantityPrice
Evista60mg28 Tablet$48.00
Evista60mg84 Tablet$80.00
Raloxifene60mg28 Tablet$22.00
Raloxifene60mg84 Tablet$48.00

Prescription Generics

false

International Brands

Act Raloxifene

Synonyms

(2-(4-Hydroxyphenyl)-6-hydroxybenzo(b)thien-3-yl)(4-(2-(1-piperidinyl)ethoxy)phenyl)methanone Keoxifene

Manufacturers

Actavis Pharma Company

CAS number

84449-90-1

UNII

YX9162EO3I

State

solid

Affected organisms

Humans and other mammals

Indication of Raloxifene

For the prevention and treatment of osteoporosis in post-menopausal women, as well as prevention and treatment of corticosteroid-induced bone loss. Also for the reduction in the incidence of invasive breast cancer in postmenopausal women with osteoporosis or have a high risk for developing breast cancer.

Toxicity of Raloxifene

Raloxifene therapy is associated with an increased risk of venous thromboembolic events such as deep-vein thrombosis, pulmonary embolism, and superficial thrombophlebitis.

RX24 Drugs Disclaimer: consult your healthcare provider before buying a Raloxifene on prescription or using an RX manufacturer savings coupon. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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