Save up -80% on Ramelteon
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Rozerem
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Ramelteon volume of distribution
Ramelteon reaches a peak plasma concentration in 0.5 to 1.5 hours (mean = 0.75) and has a volume of distribution of 73.6 L. Ramelteon is 70% protein bound to albumin.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Ramelteon
Ramelteon is the first in a new class of sleep agents that selectively binds to the melatonin receptors in the suprachiasmatic nucleus (SCN). It is used for insomnia, particularly delayed sleep onset. Ramelteon has not been shown to produce dependence and has shown no potential for abuse.
Ramelteon mechanism of action
Ramelteon is a melatonin receptor agonist with both high affinity for melatonin MT sub 1 /sub and MT sub 2 /sub receptors, and lower selectivity for the MT sub 3 /sub receptor. Melatonin production is concurrent with nocturnal sleep, meaning that an increase in melatonin levels is related to the onset of self-reported sleepiness and an increase in sleep propensity. MT sub 1 /sub receptors are believed to be responsible for regulation of sleepiness and facilitation of sleep onset, and MT sub 2 /sub receptors are believed to mediate phase-shifting effects of melatonin on the circadian rhythm. While MT sub 1 /sub and MT sub 2 /sub receptors are associated with the sleep-wake cycle, MT sub 3 /sub has a completely different profile, and therefore is not likely to be involved in the sleep-wake cycle. Remelteon has no appreciable affinity for the gamma-aminobutyric acid (GABA) receptor complex or receptors that bind neuropeptides, cytokines, serotonin, dopamine, norepinephrine, acetylcholine, or opiates.
Dosage forms of Ramelteon
|Tablet, film coated||oral||8 mg/1|
Lake Erie Medical DBA Quality Care Products LLC
Humans and other mammals
Indication of Ramelteon
For the treatment of insomnia characterized by difficulty with sleep onset.
Toxicity of Ramelteon
In humans, ramelteon has been tested in doses ranging from 4 to 64 mg. The absorption of orally administered ramelteon is at least 84%, but its absolute bioavailability is only about 1.8% because of extensive first-pass metabolism, and also, presumably, because of uptake by tissues
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