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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Rozerem

$402.3030 tablets/8mg
Price with discount in nearest pharmacy. Price may vary.

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Ramelteon volume of distribution

Ramelteon reaches a peak plasma concentration in 0.5 to 1.5 hours (mean = 0.75) and has a volume of distribution of 73.6 L. Ramelteon is 70% protein bound to albumin.

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2018 Statistics

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Discount Cards 16,000+


Clients Benefit 29%


Total savings $4,735,080

What is Ramelteon

Ramelteon is the first in a new class of sleep agents that selectively binds to the melatonin receptors in the suprachiasmatic nucleus (SCN). It is used for insomnia, particularly delayed sleep onset. Ramelteon has not been shown to produce dependence and has shown no potential for abuse.

Ramelteon mechanism of action

Ramelteon is a melatonin receptor agonist with both high affinity for melatonin MT sub 1 /sub and MT sub 2 /sub receptors, and lower selectivity for the MT sub 3 /sub receptor. Melatonin production is concurrent with nocturnal sleep, meaning that an increase in melatonin levels is related to the onset of self-reported sleepiness and an increase in sleep propensity. MT sub 1 /sub receptors are believed to be responsible for regulation of sleepiness and facilitation of sleep onset, and MT sub 2 /sub receptors are believed to mediate phase-shifting effects of melatonin on the circadian rhythm. While MT sub 1 /sub and MT sub 2 /sub receptors are associated with the sleep-wake cycle, MT sub 3 /sub has a completely different profile, and therefore is not likely to be involved in the sleep-wake cycle. Remelteon has no appreciable affinity for the gamma-aminobutyric acid (GABA) receptor complex or receptors that bind neuropeptides, cytokines, serotonin, dopamine, norepinephrine, acetylcholine, or opiates.

Dosage forms of Ramelteon

Tablet, film coatedoral8 mg/1

Prescription Generics


International Brands





Lake Erie Medical DBA Quality Care Products LLC

CAS number






Affected organisms

Humans and other mammals

Indication of Ramelteon

For the treatment of insomnia characterized by difficulty with sleep onset.

Toxicity of Ramelteon

In humans, ramelteon has been tested in doses ranging from 4 to 64 mg. The absorption of orally administered ramelteon is at least 84%, but its absolute bioavailability is only about 1.8% because of extensive first-pass metabolism, and also, presumably, because of uptake by tissues

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