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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Ranibizumab

Lucentis 0.5 mg vial

$2340.0

vial

* price without discount in nearest pharmacy. Price may vary.

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Ranibizumab volume of distribution

Volume of distribution is insignificant.

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What is Ranibizumab

Ranibizumab is a recombinant humanized IgG1 kappa isotype monoclonal antibody fragment designed for intraocular use. Ranibizumab binds to and inhibits the biologic activity of human vascular endothelial growth factor A (VEGF-A). Ranibizumab has a molecular weight of approximately 48 kilodaltons and is produced by an E. coli expression system in a nutrient medium containing the antibiotic tetracycline (tetracycline is not detectable in the final product). Ranibizumab is marketed under the name Lucentis. It is indicated for the treatment of macular edema after retinal vein occlusion, age-related macular degeneration (wet), and diabetic macular edema.

Ranibizumab mechanism of action

Ranibizumab binds to the receptor binding site of active forms of VEGF-A, including the biologically active, cleaved form of this molecule, VEGF sub110 /sub. The binding of ranibizumab to VEGF-A prevents the interaction of VEGF-A with its receptors (VEGFR1 and VEGFR2) on the surface of endothelial cells, reducing endothelial cell proliferation, vascular leakage, and new blood vessel formation.

Dosage forms of Ranibizumab

FormRouteStrength
Injection, solutionintravitreal10 mg/mL
Injection, solutionintravitreal6 mg/mL
Solutionintravitreal10 mg
Prescription Generics

false

International Brands

Lucentis

Synonyms

rhuFab V2

Manufacturers

Novartis Pharmaceuticals Canada Inc

CAS number

347396-82-1

UNII

ZL1R02VT79

State

liquid

Affected organisms

Humans and other mammals

Indication of Ranibizumab

For the treatment of patients with macular edema after retinal vein occlusion, age-related macular degeneration (wet), and diabetic macular edema.

Toxicity of Ranibizumab

The most common toxic effects to the eye are eye pain, vitreous floaters, increased intraocular pressure, conjunctival hemorrhage, intraocular inflammation, and foreign body sensation. Also arterial thromboembolic events have occurred in patients.

RX24 Drugs Disclaimer: before buying a Ranibizumab on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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