Save up -80% on Ranolazine
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Price of Ranolazine
Ranexa 500 mg tablet
* price without discount in nearest pharmacy. Price may vary.
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Ranolazine volume of distribution
What is Ranolazine
Ranolazine is an antianginal medication. On January 31, 2006, ranolazine was approved for use in the United States by the FDA for the treatment of chronic angina. (Wikipedia)
Ranolazine mechanism of action
The mechanism of action of ranolazine is unknown. It does not increase the rate-pressure product, a measure of myocardial work, at maximal exercise. In vitro studies suggest that ranolazine is a P-gp inhibitor. Ranolazine is believed to have its effects via altering the trans-cellular late sodium current. It is by altering the intracellular sodium level that ranolazine affects the sodium-dependent calcium channels during myocardial ischemia. Thus, ranolazine indirectly prevents the calcium overload that causes cardiac ischemia.
Dosage forms of Ranolazine
|Tablet, film coated, extended release||oral||1000 mg/1|
|Tablet, film coated, extended release||oral||500 mg/1|
Carilion Materials Management
Humans and other mammals
Indication of Ranolazine
For the treatment of chronic angina. It should be used in combination with amlodipine, beta-blockers or nitrates.
Toxicity of Ranolazine
In the event of overdose, the expected symptoms would be dizziness, nausea/vomiting, diplopia, paresthesia, and confusion. Syncope with prolonged loss of consciousness may develop.
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