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2018 Price of Raxibacumab
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Raxibacumab volume of distribution
Steady state volume of distribution exceeded plasma volume. This suggests that there is some distribution into the tissues.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Raxibacumab
Raxibacumab is a human IgG1 monoclonal antibody that binds the protective antigen (PA) component of B. anthracis toxin. Raxibacumab has a molecular weight of approximately 146 kilodaltons. Raxibacumab is produced by recombinant DNA technology in a murine cell expression system. FDA approved on December 14, 2012.
Raxibacumab mechanism of action
Raxibacumab is a monoclonal antibody that binds free PA with an affinity equilibrium dissociation constant (Kd) of 2.78 0.9 nM. Raxibacumab inhibits the binding of PA to its cellular receptors, preventing the intracellular entry of the anthrax lethal factor and edema factor, the enzymatic toxin components responsible for the pathogenic effects of anthrax toxin. It does not have direct antibacterial activity.
Dosage forms of Raxibacumab
Human Genome Sciences, Inc.
Indication of Raxibacumab
Raxibacumab is indicated for the treatment of adult and pediatric patients with inhalational anthrax due to Bacillus anthracis in combination with appropriate antibacterial drugs, and for prophylaxis of inhalational anthrax when alternative therapies are not available or are not appropriate.
Toxicity of Raxibacumab
The most frequently reported adverse reactions were rash, pain in extremity, pruritus, and somnolence.
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