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Price of Reserpine
Reserpine 0.25 mg tablet
* price without discount in nearest pharmacy. Price may vary.
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Reserpine volume of distribution
What is Reserpine
An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use. (PubChem)
Reserpine mechanism of action
Reserpine’s mechanism of action is through inhibition of the ATP/Mg sup 2+ /sup pump responsible for the sequestering of neurotransmitters into storage vesicles located in the presynaptic neuron. The neurotransmitters that are not sequestered in the storage vesicle are readily metabolized by monoamine oxidase (MAO) causing a reduction in catecholamines.
Dosage forms of Reserpine
Hydropres 25 Tab
Merck Frosst Canada Cie, Merck Frosst Canada Co.
Humans and other mammals
Indication of Reserpine
Foe the treatment of hypertension
Toxicity of Reserpine
Possible human carcinogen. May cause reproductive harm. ORL-RAT LD sub 50 /sub 420 mg/kg; IPR-RAT LD sub 50 /sub 44 mg/kg; IVN-RAT LD sub 50 /sub 15 mg/kg; ORL-MUS LD sub 50 /sub 200 mg/kg; SCU-MUS LD sub 50 /sub 52 mg/kg; IPR-RBT LD sub 50 /sub 7 mg/kg
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