Save up -80% on Reteplase
Note: this is a drug discount program, not an insurance plan.
2018 Price of Reteplase
Retavase vial half-kit
* price without discount in nearest pharmacy. Price may vary.
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Reteplase volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Reteplase
Human tissue plasminogen activator, purified, glycosylated, 355 residues purified from CHO cells. Retavase is considered a “third-generation” thrombolytic agent, genetically engineered to retain and delete certain portions of human tPA. Retavase is a deletion mutein of human tPA formed by deleting various amino acids present in endogenous human tPA. Retavase contains 355 of the 527 amino acids of native human tPA (amino acids 1-3 and 176-527), and retains the activity-related kringle-2 and serine protease domains of human tPA. Three domains are deleted from retavase – kringle-1, finger, and epidermal growth factor (EGF).
Reteplase mechanism of action
Reteplase binds to fibrin rich clots via the fibronectin finger-like domain and the Kringle 2 domain. The protease domain then cleaves the Arg/Val bond in plasminogen to form plasmin. Plasmin in turn degrades the fibrin matrix of the thrombus, thereby exerting its thrombolytic action.
Dosage forms of Reteplase
|Powder for solution||intravenous||10.4 unit|
t- PA t-plasminogen activator
EKR Therapeutics, Inc.
Humans and other mammals
Indication of Reteplase
For lysis of acute pulmonary emboli, intracoronary emboli and management of myocardial infarction
Toxicity of Reteplase
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