Save up -80% on Reteplase

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RX BIN: 015558
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Reteplase

Retavase vial half-kit



* price without discount in nearest pharmacy. Price may vary.

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Reteplase volume of distribution

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What is Reteplase

Human tissue plasminogen activator, purified, glycosylated, 355 residues purified from CHO cells. Retavase is considered a “third-generation” thrombolytic agent, genetically engineered to retain and delete certain portions of human tPA. Retavase is a deletion mutein of human tPA formed by deleting various amino acids present in endogenous human tPA. Retavase contains 355 of the 527 amino acids of native human tPA (amino acids 1-3 and 176-527), and retains the activity-related kringle-2 and serine protease domains of human tPA. Three domains are deleted from retavase – kringle-1, finger, and epidermal growth factor (EGF).

Reteplase mechanism of action

Reteplase binds to fibrin rich clots via the fibronectin finger-like domain and the Kringle 2 domain. The protease domain then cleaves the Arg/Val bond in plasminogen to form plasmin. Plasmin in turn degrades the fibrin matrix of the thrombus, thereby exerting its thrombolytic action.

Dosage forms of Reteplase

Powder for solutionintravenous10.4 unit
Prescription Generics


International Brands



t- PA t-plasminogen activator


EKR Therapeutics, Inc.

CAS number






Affected organisms

Humans and other mammals

Indication of Reteplase

For lysis of acute pulmonary emboli, intracoronary emboli and management of myocardial infarction

Toxicity of Reteplase

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