Save up -80% on Ribavirin
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Rebetol
|price without discount in nearest pharmacy. Price may vary.|
We offer free Rebetol coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Ribavirin every time. What are you waiting for? Claim your prescription drug card now!
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Ribavirin volume of distribution
Ribavirin is well absorbed after oral administration. However, pre-systemic drug elimination limits absolute bioavailability to 33 to 65%. The mean apparent volume of distribution (Vd) ranges from 800 to 2000 liters, indicating extensive tissue distribution. There is no significant plasma protein binding of ribavirin.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Ribavirin
A nucleoside antimetabolite antiviral agent that blocks nucleic acid synthesis and is used against both RNA and DNA viruses.
Ribavirin mechanism of action
Ribavirin is readily phosphorylated intracellularly by adenosine kinase to ribavirin mono-, di-, and triphosphate metabolites. Ribavirin triphosphate (RTP) is a potent competitive inhibitor of inosine monophosphate (IMP) dehydrogenase, viral RNA polymerase and messenger RNA (mRNA) guanylyltransferase (viral) and can be incorporated into RNA in RNA viral species.. Guanylyltranserase inhibition stops the capping of mRNA. These diverse effects result in a marked reduction of intracellular guanosine triphosphate (GTP) pools and inhibition of viral RNA and protein synthesis. Ribavirin is also incorporated into the viral genome causing lethal mutagenesis and a subsequent decrease in specific viral infectivity.
Dosage forms of Ribavirin
Hepatitis C virus, RSV and other RNA/DNA viruses
Indication of Ribavirin
For the treatment of chronic hepatitis C and for respiratory syncytial virus (RSV).
Toxicity of Ribavirin
Side effects include “flu-like” symptoms, such as headache, fatigue, myalgia, and fever. The LDsub50/sub in mice is 2 g/kg orally and is associated with hypoactivity and gastrointestinal symptoms (estimated human equivalent dose of 0.17 g/kg, based on body surface area conversion).
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