Save up -80% on Rifaximin

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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Xifaxan

$2,18860 tablets/550 mg
Price with discount in nearest pharmacy. Price may vary.

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We offer free Xifaxan coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Rifaximin every time. What are you waiting for? Claim your prescription drug card now!

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Rifaximin volume of distribution

In dogs administered 14C- rifaximin, maximum levels were measured at 1-2 h and the absorption was estimated to be 0.5% of the administered dose. Volume of distribution and clearance could not be determined and absolute bioavailability and potential for biliary excretion have not been investigated.

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2018 Statistics

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Discount Cards 16,000+


Clients Benefit 29%


Total savings $4,735,080

What is Rifaximin

Rifaximin is a semisynthetic, rifamycin-based non-systemic antibiotic, meaning that the drug will not pass the gastrointestinal wall into the circulation as is common for other types of orally administered antibiotics. It has multiple indications and is used in treatment of traveller’s diarrhea caused by E. coli; reduction in risk of overt hepatic encephalopathy recurrence; as well as diarrhea-predominant irritable bowel syndrome (IBS-D) in adult women and men. It is marketed under the brand name Xifaxan by Salix Pharmaceuticals.

Rifaximin mechanism of action

Rifaximin acts by inhibiting RNA synthesis in susceptible bacteria by binding to the beta-subunit of bacterial deoxyribonucleic acid (DNA)-dependent ribonucleic acid (RNA) polymerase enzyme. This results in the blockage of the translocation step that normally follows the formation of the first phosphodiester bond, which occurs in the transcription process.

Dosage forms of Rifaximin

Rifaximin200mg100 Tablet$152.00
Rifaximin400mg100 Tablet$135.00
Rifaximin550mg50 Tablet$86.00
Rifaximin550mg100 Tablet$163.00
Xifaxan200mg27 Tablet$109.95
Xifaxan200mg90 Tablet$331.90
Xifaxan550mg60 Tablet$1,190.00

Prescription Generics


International Brands



Rifamycin L 105 Rifamycin L 105SV


Carilion Materials Management

CAS number






Affected organisms

Enteric bacteria and other eubacteria

Indication of Rifaximin

Rifaximin has multiple indications by the FDA: for the treatment of patients (.12 years of age) with traveller’s diarrhea caused by noninvasive strains of Escherichia coli; for the reduction of overt hepatic encephalopathy recurrence in patients .18 years of age; and in May 2015 it was approved for irritable bowel syndrome with diarrhea (IBS-D) treatment in adult men and women.

Toxicity of Rifaximin

The lowest no observed adverse effect level in the toxicity tests was 25 mg/kg body weight/day in a 3-month subacute toxicity test in rats. The EMEA established a toxicological acceptable daily intake (ADI) by applying a safety factor of 100 to the no observed effect level (NOEL) of 25 mg/kg body weight/day. Neither chronic toxicity tests nor carcinogenicity tests were conducted in the EMEA assessment. Hence, the FSCJ established a toxicological ADI of 0.025 mg/kg body weight/day by applying a safety factor of 1,000 (a factor of 10 in addition to a safety factor of 100). A microbiological ADI of 0.00045 mg/kg body weight/day was established from the microbiological effects based on a current internationally recognized formula established by the International Cooperation on Harmonization of Technical Requirements for Registration of Veterinary Medicinal Products (VICH). This microbiological ADI is much smaller than the toxicological ADI of 0.025 mg/kg body weight/day calculated by applying the additional safety factor, thereby ensuring toxicological safety.

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What is Xifaxan?

Xifaxan is an antibiotic that fights bacterial infection only in the intestines. Rifaximin works differently than other antibiotics, because it passes through your stomach and into the intestines, without being absorbed into the bloodstream. Since rifaximin only treats the intestinal tract, it will not cure infections in other parts of the body.

Xifaxan is used to treat travelers’ diarrhea caused by E. coli in adults and children who are at least 12 years old. Most people get this infection by eating foods or drinking fluids that have been infected with E. coli bacteria.

Xifaxan is also used to treat irritable bowel syndrome in adults, the main symptom of which is diarrhea. Xifaxan is also used to reduce the risk of impaired brain function in adults with liver failure. Brain function can be affected when the liver stops working and cannot remove toxic substances from the body.

You should not use Xifaxan if you are allergic to rifaximin or drugs such as rifabutin (mycobutin), rifampin (rifater, rifadin, rifamant) or rifapentin (priftin). Before taking Xifaxan, tell your doctor if you have severe liver disease, diarrhea with fever, or diarrhea that is watery or has blood in it.