Save up -80% on Rifaximin
Note: this is a drug discount program, not an insurance plan.
2018 Price of Rifaximin
Xifaxan 200 mg tablet
* price without discount in nearest pharmacy. Price may vary.
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Rifaximin volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Rifaximin
Rifaximin is a semisynthetic, rifamycin-based non-systemic antibiotic, meaning that the drug will not pass the gastrointestinal wall into the circulation as is common for other types of orally administered antibiotics. It has multiple indications and is used in treatment of traveller’s diarrhea caused by E. coli; reduction in risk of overt hepatic encephalopathy recurrence; as well as diarrhea-predominant irritable bowel syndrome (IBS-D) in adult women and men. It is marketed under the brand name Xifaxan by Salix Pharmaceuticals.
Rifaximin mechanism of action
Rifaximin acts by inhibiting RNA synthesis in susceptible bacteria by binding to the beta-subunit of bacterial deoxyribonucleic acid (DNA)-dependent ribonucleic acid (RNA) polymerase enzyme. This results in the blockage of the translocation step that normally follows the formation of the first phosphodiester bond, which occurs in the transcription process.
Dosage forms of Rifaximin
Rifamycin L 105 Rifamycin L 105SV
Carilion Materials Management
Enteric bacteria and other eubacteria
Indication of Rifaximin
Rifaximin has multiple indications by the FDA: for the treatment of patients (.12 years of age) with traveller’s diarrhea caused by noninvasive strains of Escherichia coli; for the reduction of overt hepatic encephalopathy recurrence in patients .18 years of age; and in May 2015 it was approved for irritable bowel syndrome with diarrhea (IBS-D) treatment in adult men and women.
Toxicity of Rifaximin
LD sub50 /sub 2 g/kg (orally, in rats)
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