Save up -80% on Rifaximin
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
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2019 Price of Xifaxan
|$2,188||60 tablets/550 mg|
|price without discount in nearest pharmacy. Price may vary.|
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Rifaximin volume of distribution
In dogs administered 14C- rifaximin, maximum levels were measured at 1-2 h and the absorption was estimated to be 0.5% of the administered dose. Volume of distribution and clearance could not be determined and absolute bioavailability and potential for biliary excretion have not been investigated.
Discount Cards 16,000+
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Total savings $4,735,080
What is Rifaximin
Rifaximin is a semisynthetic, rifamycin-based non-systemic antibiotic, meaning that the drug will not pass the gastrointestinal wall into the circulation as is common for other types of orally administered antibiotics. It has multiple indications and is used in treatment of traveller’s diarrhea caused by E. coli; reduction in risk of overt hepatic encephalopathy recurrence; as well as diarrhea-predominant irritable bowel syndrome (IBS-D) in adult women and men. It is marketed under the brand name Xifaxan by Salix Pharmaceuticals.
Rifaximin mechanism of action
Rifaximin acts by inhibiting RNA synthesis in susceptible bacteria by binding to the beta-subunit of bacterial deoxyribonucleic acid (DNA)-dependent ribonucleic acid (RNA) polymerase enzyme. This results in the blockage of the translocation step that normally follows the formation of the first phosphodiester bond, which occurs in the transcription process.
Dosage forms of Rifaximin
Rifamycin L 105 Rifamycin L 105SV
Carilion Materials Management
Enteric bacteria and other eubacteria
Indication of Rifaximin
Rifaximin has multiple indications by the FDA: for the treatment of patients (.12 years of age) with traveller’s diarrhea caused by noninvasive strains of Escherichia coli; for the reduction of overt hepatic encephalopathy recurrence in patients .18 years of age; and in May 2015 it was approved for irritable bowel syndrome with diarrhea (IBS-D) treatment in adult men and women.
Toxicity of Rifaximin
The lowest no observed adverse effect level in the toxicity tests was 25 mg/kg body weight/day in a 3-month subacute toxicity test in rats. The EMEA established a toxicological acceptable daily intake (ADI) by applying a safety factor of 100 to the no observed effect level (NOEL) of 25 mg/kg body weight/day. Neither chronic toxicity tests nor carcinogenicity tests were conducted in the EMEA assessment. Hence, the FSCJ established a toxicological ADI of 0.025 mg/kg body weight/day by applying a safety factor of 1,000 (a factor of 10 in addition to a safety factor of 100). A microbiological ADI of 0.00045 mg/kg body weight/day was established from the microbiological effects based on a current internationally recognized formula established by the International Cooperation on Harmonization of Technical Requirements for Registration of Veterinary Medicinal Products (VICH). This microbiological ADI is much smaller than the toxicological ADI of 0.025 mg/kg body weight/day calculated by applying the additional safety factor, thereby ensuring toxicological safety.
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What is Xifaxan?
Xifaxan is an antibiotic that fights bacterial infection only in the intestines. Rifaximin works differently than other antibiotics, because it passes through your stomach and into the intestines, without being absorbed into the bloodstream. Since rifaximin only treats the intestinal tract, it will not cure infections in other parts of the body.
Xifaxan is used to treat travelers’ diarrhea caused by E. coli in adults and children who are at least 12 years old. Most people get this infection by eating foods or drinking fluids that have been infected with E. coli bacteria.
Xifaxan is also used to treat irritable bowel syndrome in adults, the main symptom of which is diarrhea. Xifaxan is also used to reduce the risk of impaired brain function in adults with liver failure. Brain function can be affected when the liver stops working and cannot remove toxic substances from the body.
You should not use Xifaxan if you are allergic to rifaximin or drugs such as rifabutin (mycobutin), rifampin (rifater, rifadin, rifamant) or rifapentin (priftin). Before taking Xifaxan, tell your doctor if you have severe liver disease, diarrhea with fever, or diarrhea that is watery or has blood in it.